Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A
	Deng, Xu1 ; Liang, Kangjiang 1,2; Tong, Xiaogang 1,2; Ding, Ming 1,2; Li, Dashan 1,2; Xia, Chengfeng 1
刊名	ORGANIC LETTERS
	2014-06-20
卷号	16 期号:12 页码:3276-3279
关键词	PHYSICOCHEMICAL PROPERTIES TRYPTOPHAN DERIVATIVES GYPSETIN CONFIGURATION FERMENTATION INHIBITOR CHEMISTRY DISCOVERY INDOLES NW-G01
ISSN号	1523-7060
通讯作者	Xia,CF (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; xiachengfeng@mail.kib.ac.cn
英文摘要	An unprecedented copper-catalyzed intramolecular radical cyclization was developed for the synthesis of 3-hydroxypyrroloindoline skeletons in excellent yields. The 3-hydroxyl group was introduced by trapping the radical intermediate with molecular oxygen or TEMPO. This process represents a unique radical oxidation pathway for tryptamine/tryptophan derivatives and allows a rapid biomimetic synthesis of natural product protubonine A.
学科主题	Chemistry, Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	PHYSICOCHEMICAL PROPERTIES ; TRYPTOPHAN DERIVATIVES ; GYPSETIN ; CONFIGURATION ; FERMENTATION ; INHIBITOR ; CHEMISTRY ; DISCOVERY ; INDOLES ; NW-G01
收录类别	SCI ; IC ; CCR
资助信息	National Natural Science Foundation of China [21272242, 21302193];Yunnan High-End Technology Professionals Introduction Program [2010CI117];National Basic Research Program of China [2011CB915500]
语种	英语
WOS记录号	WOS:000337869800027
公开日期	2014-07-28
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18182]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Deng, Xu,Liang, Kangjiang,Tong, Xiaogang,et al. Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A[J]. ORGANIC LETTERS,2014,16(12):3276-3279.
APA	Deng, Xu,Liang, Kangjiang,Tong, Xiaogang,Ding, Ming,Li, Dashan,&Xia, Chengfeng.(2014).Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A.ORGANIC LETTERS,16(12),3276-3279.
MLA	Deng, Xu,et al."Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A".ORGANIC LETTERS 16.12(2014):3276-3279.