The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica

	The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica
	Jin, Weihua 1,2,3; Wang, Jing1,3 ; Jiang, Hong 4; Song, Ning 4; Zhang, Wenjing1,2 ; Zhang, Quanbin 1,3
刊名	CARBOHYDRATE POLYMERS
	2013-08-14
卷号	97 期号:1 页码:116-120
关键词	Heteropolysaccharide Neuroprotective activity Saccharina japonica
ISSN号	0144-8617
通讯作者	Zhang, QB
中文摘要	Crude fucoidan extracted from Saccharina japonica was separated by anion-exchange chromatography. Then, the neuroprotective activities of the crude fucoidan (J) and its fractions (J0.4, J0.5, J1 and J2) were tested. J, J0.4 and J0.5 were shown to have neuroprotective effects. To simplify the structural features of the compounds, crude fucoidan was degraded to obtain low molecular weight fucoidan (DJ). DJ was further fractionated into DJ0.5, DJ1 and DJ2, and the neuroprotective activities of these fractions were determined. This analysis revealed that DJ and DJ0.5 retained the neuroprotective activity. However, the DJ0.5 fraction remained very complex. Thus, DJ0.5 was further separated into six fractions (F0.1, F0.2, F0.3, F0.4, F0.5 and F1). Finally, it was concluded that the anion-exchange fractions F0.1, F0.2 and F0.3 exhibited neuroprotective activities. These results suggest that heteropolysaccharides might contribute to the neuroprotective activity. Moreover, the neuroprotective heteropolysaccharide fractions contained relatively low fucose (less than 20%) and sulfate (25%), high UA content (more than 10%) and a high molar ratio of all other monosaccharides (C) 2013 Elsevier Ltd. All rights reserved.
英文摘要	Crude fucoidan extracted from Saccharina japonica was separated by anion-exchange chromatography. Then, the neuroprotective activities of the crude fucoidan (J) and its fractions (J0.4, J0.5, J1 and J2) were tested. J, J0.4 and J0.5 were shown to have neuroprotective effects. To simplify the structural features of the compounds, crude fucoidan was degraded to obtain low molecular weight fucoidan (DJ). DJ was further fractionated into DJ0.5, DJ1 and DJ2, and the neuroprotective activities of these fractions were determined. This analysis revealed that DJ and DJ0.5 retained the neuroprotective activity. However, the DJ0.5 fraction remained very complex. Thus, DJ0.5 was further separated into six fractions (F0.1, F0.2, F0.3, F0.4, F0.5 and F1). Finally, it was concluded that the anion-exchange fractions F0.1, F0.2 and F0.3 exhibited neuroprotective activities. These results suggest that heteropolysaccharides might contribute to the neuroprotective activity. Moreover, the neuroprotective heteropolysaccharide fractions contained relatively low fucose (less than 20%) and sulfate (25%), high UA content (more than 10%) and a high molar ratio of all other monosaccharides (C) 2013 Elsevier Ltd. All rights reserved.
学科主题	Chemistry ; Polymer Science
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]	Chemistry ; Polymer Science
关键词[WOS]	HIZIKIA-FUSIFORME ; SULFATED POLYSACCHARIDES ; ANTICOAGULANT ACTIVITY ; LAMINARIA-JAPONICA ; BROWN SEAWEED ; CID-MS/MS ; FUCOIDAN ; CELLS
收录类别	SCI
原文出处	10.1016/j.carbpol.2013.04.055
语种	英语
WOS记录号	WOS:000321167300017
公开日期	2014-07-17
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/16727]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.IOCAS, Nantong Marine Sci & Technol R&D Ctr, Nantong 226006, Jiangsu, Peoples R China 4.Qingdao Univ, Dept Physiol, Coll Med, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Jin, Weihua,Wang, Jing,Jiang, Hong,et al. The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica[J]. CARBOHYDRATE POLYMERS,2013,97(1):116-120.
APA	Jin, Weihua,Wang, Jing,Jiang, Hong,Song, Ning,Zhang, Wenjing,&Zhang, Quanbin.(2013).The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica.CARBOHYDRATE POLYMERS,97(1),116-120.
MLA	Jin, Weihua,et al."The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica".CARBOHYDRATE POLYMERS 97.1(2013):116-120.