Arsenic Levels and Speciation from Ingestion Exposures to Biomarkers in Shanxi, China: Implications for Human Health

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Arsenic Levels and Speciation from Ingestion Exposures to Biomarkers in Shanxi, China: Implications for Human Health
	Cui, Jinli ; Shi, Jianbo ; Jiang, Guibin ; Jing, Chuanyong
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2013
卷号	47 期号:10 页码:5419-5424
通讯作者	Jing, CY
中文摘要	Chronic exposure to arsenic (As) threatens human health. To systematically understand the health risks induced by As ingestion, we explored water and diet contributions to As exposure, and compared As in biomarkers and the arsenicosis in a geogenic As area in China. In this study, high percentages of water (77% of n = 131 total samples), vegetables (92%, n = 120), cereals (32%, n = 25), urine (70%, n = 99), nails (76%, n = 176), and hair (62%, n = 61) contained As higher than the acceptable levels. Dietary As contributed 92% of the average daily dose (ADD) when the water As concentration was less than 10 mu g/L, for which 5 out of 30 examined participants were diagnosed with arsenicosis symptoms. The distinct positive correlation between ADD and As concentrations in urine, nails, and hair suggests different applicability for these biomarkers. Methylated As as the predominant urinary As species confirms that the ingested inorganic As is methylated and is excreted through urine. In situ microdistribution and speciation analysis indicates that As is mainly associated with sulfur in nails and hair. Nails, rather than hair and urine, could be used as a proper biomarker for arsenicosis. High ADD from the environment and low excretion could result in As toxicity to humans.
收录类别	SCI
WOS记录号	WOS:000319708600055
公开日期	2014-06-06
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/7496]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Cui, Jinli,Shi, Jianbo,Jiang, Guibin,et al. Arsenic Levels and Speciation from Ingestion Exposures to Biomarkers in Shanxi, China: Implications for Human Health[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2013,47(10):5419-5424.
APA	Cui, Jinli,Shi, Jianbo,Jiang, Guibin,&Jing, Chuanyong.(2013).Arsenic Levels and Speciation from Ingestion Exposures to Biomarkers in Shanxi, China: Implications for Human Health.ENVIRONMENTAL SCIENCE & TECHNOLOGY,47(10),5419-5424.
MLA	Cui, Jinli,et al."Arsenic Levels and Speciation from Ingestion Exposures to Biomarkers in Shanxi, China: Implications for Human Health".ENVIRONMENTAL SCIENCE & TECHNOLOGY 47.10(2013):5419-5424.