Label-free acoustic and optical biosensors playing on evanescent waves

CORC > 长春光学精密机械与物理研究所 > 中国科学院长春光学精密机械与物理研究所 > 中科院长春光机所知识产出 > 会议论文

	Label-free acoustic and optical biosensors playing on evanescent waves
	Wu Y. ; Liu G. ; Hao P. ; Wu J. ; Deng Y. ; Liu Y. ; Xuan M.
	2013
会议名称	Progress in Electromagnetics Research Symposium, PIERS 2013 Stockholm, August 12, 2013 - August 15, 2013
会议地点	Stockholm, Sweden
页码	1756-1771
英文摘要	Development of sensitive, reliable, high-throughput, label-free detection techniques is an issue with increasing emphasis because the labeling strategies that most of the microarray applications have employed, such as fluorescent, chemiluminescent and radioactive labeling, have synthetic challenges, multiple label issues and may exhibit interference with the binding sites. Label-free detection techniques monitor biomolecular interactions and simplify the bioassays by eliminating the need for secondary reactants. Especially, biosensors based on evanescent waves often have high sensitivities by recording the changes caused by the molecule interaction near the sensor surface within the evanescent field, and moreover they provide quantitative information for the binding kinetics. In this article, we will describe the similarity of sound waves and electromagnetic waves and review the biosensors to which the two types of label-free techniques are related. The theoretical and technical outlines behind the sensing principles, such as the evanescent waves scattering, interference, resonance and tunnel effects, will be summarized. The physical mechanisms to modulate waves by micro/nano structures, which localize the waves, amplify the signal/noise ratio and increase Q factor for high sensitivity and high resolution, will also be discussed. Moreover, the promising acousto-optic sensing mechanism and the possibility of multi-parameter decoupling detection will be mentioned. The potential prospects, merits and challenges of these kinds of biosensors are also indicated.
收录类别	EI
会议录	Progress in Electromagnetics Research Symposium, PIERS 2013 Stockholm, August 12, 2013 - August 15, 2013
会议录出版者	Electromagnetics Academy
会议录出版地	Stockholm, Sweden
内容类型	会议论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/41060]
专题	长春光学精密机械与物理研究所_中科院长春光机所知识产出_会议论文
推荐引用方式 GB/T 7714	Wu Y.,Liu G.,Hao P.,et al. Label-free acoustic and optical biosensors playing on evanescent waves[C]. 见:Progress in Electromagnetics Research Symposium, PIERS 2013 Stockholm, August 12, 2013 - August 15, 2013. Stockholm, Sweden.