Cytotoxic Amides and Quinolones from Clausena lansium

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic Amides and Quinolones from Clausena lansium
	Song, Wei-Wu 1,2; Zeng, Guang-Zhi 1; Peng, Wen-Wen 1; Chen, Ke-Xian 1,2; Tan, Ning-Hua 1
刊名	HELVETICA CHIMICA ACTA
	2014-02-01
卷号	97 期号:2 页码:298-305
关键词	Quinolones Clausena lansium Cytotoxic activity Claulansamides A and B Amides
ISSN号	0018-019X
英文摘要	Two new amides, claulansamides A and B (1 and 2, resp.), together with five known amides, 3-7 and six known quinolones, 8-13, were isolated from the stems and roots of Clausena lansium. Their structures were elucidated on the basis of extensive spectroscopic methods. Their absolute configurations were determined by single-crystal X-ray diffraction technique, CD, and optical rotation. HPLC Chiral separation of 1 afforded two enantiomers, (+)- and (-)-claulansamide A, respectively. Compounds 9, 12, and 13 were isolated from the genus Clausena for the first time. All compounds were evaluated for their cytotoxic activities against A549, BGC-823, and HeLa cancer cell lines. However, only 9 showed cytotoxic activity against A549 cell line with an IC50 value of 46.3 mu M, and 11 against BGC-823 and HeLa cell lines with the IC50 values of 55.0 and 14.7 mu M, respectively.
学科主题	Chemistry, Multidisciplinary
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	CHEMICAL-CONSTITUENTS ; CARBAZOLE ALKALOIDS ; COUMARIN ; ANISATA ; SEEDS ; STEMS
收录类别	SCI ; IC
资助信息	National New Drug Innovation Major Project of China [2011ZX09307-002-02]; National Natural Science Foundation of China [U1032602, 91013002, 30725048]; National Basic Research Program of China [2009CB522300]; Fund of Chinese Academy of Sciences (Hundred Talents Program); Natural Science Foundation of Yunnan Province [2012GA003]
语种	英语
WOS记录号	WOS:000331959500012
公开日期	2014-05-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18055]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Song, Wei-Wu,Zeng, Guang-Zhi,Peng, Wen-Wen,et al. Cytotoxic Amides and Quinolones from Clausena lansium[J]. HELVETICA CHIMICA ACTA,2014,97(2):298-305.
APA	Song, Wei-Wu,Zeng, Guang-Zhi,Peng, Wen-Wen,Chen, Ke-Xian,&Tan, Ning-Hua.(2014).Cytotoxic Amides and Quinolones from Clausena lansium.HELVETICA CHIMICA ACTA,97(2),298-305.
MLA	Song, Wei-Wu,et al."Cytotoxic Amides and Quinolones from Clausena lansium".HELVETICA CHIMICA ACTA 97.2(2014):298-305.