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	Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A beta oligomer level and attenuating oxidative stress and neuroinflammation
	Xu, Peng-xin1,2; Wang, Shao-wei1; Yu, Xiao-lin1; Su, Ya-jing1,2; Wang, Teng1; Zhou, Wei-wei1; Zhang, He1; Wang, Yu-jiong2; Liu, Rui-tian1
刊名	BEHAVIOURAL BRAIN RESEARCH
	2014-05-01
卷号	264期号:1页码:173-180
关键词	Rutin Alzheimer's disease beta-Amyloid Oligomer Oxidative stress Neuroinflammation
ISSN号	0166-4328
其他题名	Behav. Brain Res.
中文摘要	Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by extracellular beta-amyloid (A beta) plaques and intracellular neurofibrillary tangles in the brain. A beta aggregation is closely associated with neurotoxicity, oxidative stress, and neuronal inflammation. The soluble A beta oligomers are believed to be the most neurotoxic form among all forms of A beta aggregates. We have previously reported a polyphenol compound rutin that could inhibit A beta aggregation and cytotoxicity, attenuate oxidative stress, and decrease the production of nitric oxide and proinflammatory cytokines in vitro. In the current study, we investigated the effect of rutin on APPswe/PS1dE9 transgenic mice. Results demonstrated that orally administered rutin significantly attenuated memory deficits in AD transgenic mice, decreased oligomeric A beta level, increased super oxide dismutase (SOD) activity and glutathione (GSH)/glutathione disulfide (GSSG) ratio, reduced GSSG and malondialdehyde (MDA) levels, downregulated microgliosis and astrocytosis, and decreased interleukin (IL)-1 beta and IL-6 levels in the brain. These results indicated that rutin is a promising agent for AD treatment because of its antioxidant, anti-inflammatory, and reducing A beta oligomer activities. (C) 2014 Elsevier B.V. All rights reserved.
英文摘要	Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by extracellular beta-amyloid (A beta) plaques and intracellular neurofibrillary tangles in the brain. A beta aggregation is closely associated with neurotoxicity, oxidative stress, and neuronal inflammation. The soluble A beta oligomers are believed to be the most neurotoxic form among all forms of A beta aggregates. We have previously reported a polyphenol compound rutin that could inhibit A beta aggregation and cytotoxicity, attenuate oxidative stress, and decrease the production of nitric oxide and proinflammatory cytokines in vitro. In the current study, we investigated the effect of rutin on APPswe/PS1dE9 transgenic mice. Results demonstrated that orally administered rutin significantly attenuated memory deficits in AD transgenic mice, decreased oligomeric A beta level, increased super oxide dismutase (SOD) activity and glutathione (GSH)/glutathione disulfide (GSSG) ratio, reduced GSSG and malondialdehyde (MDA) levels, downregulated microgliosis and astrocytosis, and decreased interleukin (IL)-1 beta and IL-6 levels in the brain. These results indicated that rutin is a promising agent for AD treatment because of its antioxidant, anti-inflammatory, and reducing A beta oligomer activities. (C) 2014 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]	SOLUBLE AMYLOID OLIGOMERS ; PROTEIN ; RATS ; POLYPHENOLS ; ISCHEMIA ; INJURY ; BRAIN ; PERMEABILIZATION ; BIOAVAILABILITY ; INFLAMMATION
收录类别	SCI
原文出处	://WOS:000333853300019
语种	英语
WOS记录号	WOS:000333853300019
公开日期	2014-05-06
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/8197]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Ningxia Univ, Sch Life Sci, Yinchuan 750021, Peoples R China
推荐引用方式 GB/T 7714	Xu, Peng-xin,Wang, Shao-wei,Yu, Xiao-lin,et al. Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A beta oligomer level and attenuating oxidative stress and neuroinflammation[J]. BEHAVIOURAL BRAIN RESEARCH,2014,264(1):173-180.
APA	Xu, Peng-xin.,Wang, Shao-wei.,Yu, Xiao-lin.,Su, Ya-jing.,Wang, Teng.,...&Liu, Rui-tian.(2014).Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A beta oligomer level and attenuating oxidative stress and neuroinflammation.BEHAVIOURAL BRAIN RESEARCH,264(1),173-180.
MLA	Xu, Peng-xin,et al."Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A beta oligomer level and attenuating oxidative stress and neuroinflammation".BEHAVIOURAL BRAIN RESEARCH 264.1(2014):173-180.

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