Studies on Serum of Arsenic Trioxide Treated Rats by H-1 NMR Based Metabonomics

	Studies on Serum of Arsenic Trioxide Treated Rats by H-1 NMR Based Metabonomics
	Zhang PP ; Zhang WJ ; Xue R ; Li XJ ; Yan W ; Pei FK
刊名	chinese journal of analytical chemistry
	2013
卷号	41 期号:9 页码:1434-1438
关键词	OXIDATIVE STRESS CARCINOGENESIS SPECTROSCOPY METABOLISM INDUCTION TOXICITY SYSTEMS URINE CELLS ACID
ISSN号	0253-3820
通讯作者	li xj
中文摘要	the metabolites of rats' serum caused by arsenic trioxide intragastric infusion (dosed at 2, 10 mg/kg body weight, respectively) were investigated through metabonomics. the metabolic profiling detected by nmr subjected to principal component analysis (pca), which find out the different metabolites of the control group and arsenic trioxide treated group, to explore the acute biological effects. the results revealed that arsenic trioxide caused acute damage on rats' liver, and the toxicity effect increased with the increase of dose. low dosage administration arsenic trioxide gave rise to reactive oxygen species (ros), and high dosage administration arsenic trioxide induced cell apoptosis. sugar, amino acid fat metabolism disorder and energy metabolism abnormality occurred in both low and high dosed rats.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000329520400020
公开日期	2014-04-20
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50465]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang PP,Zhang WJ,Xue R,et al. Studies on Serum of Arsenic Trioxide Treated Rats by H-1 NMR Based Metabonomics[J]. chinese journal of analytical chemistry,2013,41(9):1434-1438.
APA	Zhang PP,Zhang WJ,Xue R,Li XJ,Yan W,&Pei FK.(2013).Studies on Serum of Arsenic Trioxide Treated Rats by H-1 NMR Based Metabonomics.chinese journal of analytical chemistry,41(9),1434-1438.
MLA	Zhang PP,et al."Studies on Serum of Arsenic Trioxide Treated Rats by H-1 NMR Based Metabonomics".chinese journal of analytical chemistry 41.9(2013):1434-1438.