Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery

	Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery
	Chen ZW ; Li ZH ; Lin YH ; Yin ML ; Ren JS ; Qu XG
刊名	chemistry-a european journal
	2013
卷号	19 期号:5 页码:1778-1783
关键词	GUEST MOLECULES CANCER-THERAPY RELEASE CD44 RECEPTOR SYSTEM FUNCTIONALIZATION NANOVALVES CATABOLISM TRANSPORT
ISSN号	0947-6539
通讯作者	ren js
中文摘要	in this paper, we present a facile strategy to synthesize hyaluronic acid (ha) conjugated mesoporous silica nanoparticles (msp) for targeted enzyme responsive drug delivery, in which the anchored ha polysaccharides not only act as capping agents but also as targeting ligands without the need of additional modification. the nanoconjugates possess many attractive features including chemical simplicity, high colloidal stability, good biocompatibility, cell-targeting ability, and precise cargo release, making them promising agents for biomedical applications. as a proof-of-concept demonstration, the nanoconjugates are shown to release cargoes from the interior pores of msps upon ha degradation in response to hyaluronidase-1 (hyal-1). moreover, after receptor-mediated endocytosis into cancer cells, the anchored ha was degraded into small fragments, facilitating the release of drugs to kill the cancer cells. overall, we envision that this system might open the door to a new generation of carrier system for site-selective, controlled-release delivery of anticancer drugs.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000313787700036
公开日期	2014-04-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50390]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Chen ZW,Li ZH,Lin YH,et al. Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery[J]. chemistry-a european journal,2013,19(5):1778-1783.
APA	Chen ZW,Li ZH,Lin YH,Yin ML,Ren JS,&Qu XG.(2013).Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery.chemistry-a european journal,19(5),1778-1783.
MLA	Chen ZW,et al."Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery".chemistry-a european journal 19.5(2013):1778-1783.