pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery

	pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery
	Yu SJ ; He CL ; Ding JX ; Cheng YL ; Song WT ; Zhuang XL ; Chen XS
刊名	soft matter
	2013
卷号	9 期号:9 页码:2637-2645
关键词	POLYMERIC MICELLES BIODEGRADABLE POLYURETHANES SUPRAMOLECULAR ASSEMBLIES POLYPEPTIDE NANOGELS BLOCK-COPOLYMERS RELEASE VESICLES DOXORUBICIN HYDROGELS THERAPY
ISSN号	1744-683x
通讯作者	he cl
中文摘要	a series of ph/reduction dual responsive poly(ethylene glycol)/polyurethane triblock copolymers containing tertiary amines and disulfide bonds are reported. the polyurethane block copolymers self-assembled into stable micelles in aqueous medium at ph 7.4, which responded rapidly to both a narrow ph change within the physiologically relevant ph range and a reduction environment mimicking the intracellular space. the in vitro drug release from doxorubicin (dox)-loaded polyurethane micelles was significantly accelerated by reducing the ph or by addition of an intracellular reducing agent, glutathione (gsh). confocal laser scanning microscopy (clsm) and flow cytometry measurements revealed that the intracellular drug release from the dox-loaded nanoparticles was increased in the hela cells with enhanced intracellular gsh level. in addition, even though the polyurethane block copolymers exhibited good cytocompatibility, the dox-loaded polyurethane micelles displayed efficient growth inhibition of hela and hepg2 cells, which showed a dependence on the intracellular gsh concentration. owing to their unique responsiveness to dual biological stimuli, the biocompatible and bioreducible polyurethane block copolymers have the potential to serve as a versatile platform for intracellular drug delivery.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000314654700010
公开日期	2014-04-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50388]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Yu SJ,He CL,Ding JX,et al. pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery[J]. soft matter,2013,9(9):2637-2645.
APA	Yu SJ.,He CL.,Ding JX.,Cheng YL.,Song WT.,...&Chen XS.(2013).pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery.soft matter,9(9),2637-2645.
MLA	Yu SJ,et al."pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery".soft matter 9.9(2013):2637-2645.