Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro

	Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro
	Ding JX ; Chen JJ ; Li D ; Xiao CS ; Zhang JC ; He CL ; Zhuang XL ; Chen XS
刊名	journal of materials chemistry b
	2013
卷号	1 期号:1 页码:69-81
关键词	INTRACELLULAR DRUG-DELIVERY BLOCK-COPOLYMER POLYMERIC MICELLES POLY(L-GLUTAMIC ACID) PH NANOGELS RELEASE CARRIER L-GLUTAMATE) DOXORUBICIN
ISSN号	2050-750x
通讯作者	ding jx
中文摘要	to develop biocompatible reduction-responsive micellar systems for efficient intracellular drug delivery, disulfide-linked block copolymers of methoxyl poly(ethylene glycol) (mpeg) and poly(epsilon-benzyloxycarbonyl-(l)-lysine) (pzll) were synthesized through ring-opening polymerization of epsilon-benzyloxycarbonyl-(l)-lysine n-carboxyanhydride with amino group terminated disulfide functionalized mpeg as macroinitiator. the copolymers self-assembled into micelles in phosphate buffered saline (pbs) at ph 7.4 through direct dissolution and dialysis methods. the micelles were revealed to have excellent hemocompatibilities, and cell and tissue compatibilities, which rendered them with potential for drug delivery applications. doxorubicin (dox), an anthracycline antitumor drug, was loaded into the micelles through nanoprecipitation with a drug loading efficiency of about 30 wt%. the in vitro dox release from all dox-loaded micelles was accelerated in pbs with 10.0 mm gsh, mimicking intracellular reductive conditions. dox-loaded micelles showed higher cellular proliferation inhibition towards glutathione monoester pretreated hela (a human cervical cell line) and hepg2 cells (a human hepatoma cell line) as compared to unpretreated or buthionine sulfoximine pretreated cells. the above results indicated that the biocompatible reduction-responsive micelles have vast potential in targeted intracellular delivery of antitumor drugs to achieve enhanced efficacy in malignancy therapy.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000314784900008
公开日期	2014-04-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50366]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Ding JX,Chen JJ,Li D,et al. Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro[J]. journal of materials chemistry b,2013,1(1):69-81.
APA	Ding JX.,Chen JJ.,Li D.,Xiao CS.,Zhang JC.,...&Chen XS.(2013).Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro.journal of materials chemistry b,1(1),69-81.
MLA	Ding JX,et al."Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro".journal of materials chemistry b 1.1(2013):69-81.