PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity

	PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity
	Liu Z ; Pu F ; Liu JH ; Jiang LY ; Yuan QH ; Li ZQ ; Ren JS ; Qu XG
刊名	nanoscale
	2013
卷号	5 期号:10 页码:4252-4261
关键词	UP-CONVERSION NANOPARTICLES COATED GOLD NANOPARTICLES LARGE-SCALE SYNTHESIS CONTRAST AGENTS SILICA NANOPARTICLES DRUG-DELIVERY SULFIDE NANOPARTICLES HEMOLYTIC-ACTIVITY GADOLINIUM NANOCRYSTALS
ISSN号	2040-3364
通讯作者	ren js
中文摘要	novel nanoparticulate contrast agents with low systemic toxicity and inexpensive character have exhibited more advantages over routinely used small molecular contrast agents for the diagnosis and prognosis of disease. herein, we designed and synthesized pegylated hybrid ytterbia nanoparticles as high-performance nanoprobes for x-ray computed tomography (ct) imaging and magnetic resonance (mr) imaging both in vitro and in vivo. these well-defined nanoparticles were facile to prepare and cost-effective, meeting the criteria as a biomedical material. compared with routinely used iobitridol in clinic, our peg-yb2o3:gd nanoparticles could provide much significantly enhanced contrast upon various clinical voltages ranging from 80 kvp to 140 kvp owing to the high atomic number and well-positioned k-edge energy of ytterbium. by the doping of gadolinium, our nanoparticulate contrast agent could perform perfect mr imaging simultaneously, revealing similar organ enrichment and bio-distribution with the ct imaging results. the super improvement in imaging efficiency was mainly attributed to the high content of yb and gd in a single nanoparticle, thus making these nanoparticles suitable for dual-modal diagnostic imaging with a low single-injection dose. in addition, detailed toxicological study in vitro and in vivo indicated that uniformly sized peg-yb2o3:gd nanoparticles possessed excellent biocompatibility and revealed overall safety.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000318362400032
公开日期	2014-04-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50298]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu Z,Pu F,Liu JH,et al. PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity[J]. nanoscale,2013,5(10):4252-4261.
APA	Liu Z.,Pu F.,Liu JH.,Jiang LY.,Yuan QH.,...&Qu XG.(2013).PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity.nanoscale,5(10),4252-4261.
MLA	Liu Z,et al."PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity".nanoscale 5.10(2013):4252-4261.