Intracellular pH-sensitive supramolecular amphiphiles based on host-guest recognition between benzimidazole and beta-cyclodextrin as potential drug delivery vehicles

	Intracellular pH-sensitive supramolecular amphiphiles based on host-guest recognition between benzimidazole and beta-cyclodextrin as potential drug delivery vehicles
	Zhang Z ; Ding JX ; Chen XF ; Xiao CS ; He CL ; Zhuang XL ; Chen L ; Chen XS
刊名	polymer chemistry
	2013
卷号	4 期号:11 页码:3265-3271
关键词	VESICLES NANOPARTICLES NETWORKS MICELLES CARRIERS RELEASE
ISSN号	1759-9954
通讯作者	he cl
中文摘要	intracellular ph-sensitive supramolecular block amphiphiles based on the host-guest interaction between benzimidazole (bm) modified poly(epsilon-caprolactone) (bm-pcl) and cyclodextrin (beta-cd) terminated dextran (dex-beta-cd) were designed. the supramolecular block amphiphiles could further self-assemble into supramolecular micelles and exhibit ph-sensitive behaviour in acidic aqueous solution when the ph value was below 6. doxorubicin (dox), a model anticancer drug, was effectively loaded into the supramolecular micelles via hydrophobic interactions. the dox release from all dox-loaded micelles was accelerated in acid conditions mimicking the endosomal/lysosomal compartments. the enhanced intracellular dox release was observed in hepg2 cells. dox-loaded intracellular ph-sensitive supramolecular micelles showed higher cellular proliferation inhibition towards hepg2 cells than ph-insensitive micelles. these features suggested that the supramolecular micelles could efficiently load and deliver dox into tumor cells and enhance the inhibition of cellular proliferation in vitro, providing a powerful mean for delivering and releasing cargoes at the tumor sites.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000318557600012
公开日期	2014-04-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50291]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang Z,Ding JX,Chen XF,et al. Intracellular pH-sensitive supramolecular amphiphiles based on host-guest recognition between benzimidazole and beta-cyclodextrin as potential drug delivery vehicles[J]. polymer chemistry,2013,4(11):3265-3271.
APA	Zhang Z.,Ding JX.,Chen XF.,Xiao CS.,He CL.,...&Chen XS.(2013).Intracellular pH-sensitive supramolecular amphiphiles based on host-guest recognition between benzimidazole and beta-cyclodextrin as potential drug delivery vehicles.polymer chemistry,4(11),3265-3271.
MLA	Zhang Z,et al."Intracellular pH-sensitive supramolecular amphiphiles based on host-guest recognition between benzimidazole and beta-cyclodextrin as potential drug delivery vehicles".polymer chemistry 4.11(2013):3265-3271.