A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps

	A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps
	He HY ; Kuang HH ; Yan LS ; Meng FB ; Xie ZG ; Jing XB ; Huang YB
刊名	physical chemistry chemical physics
	2013
卷号	15 期号:34 页码:14210-14218
关键词	RESPONSIVE CONTROLLED-RELEASE ANTICANCER DRUG-DELIVERY GOLD NANOPARTICLES MOLECULES MICELLES CANCER CORE GENE
ISSN号	1463-9076
通讯作者	meng fb
中文摘要	mesoporous silica nanoparticles (msn)-polymer hybrid combined with the aliphatic biodegradable polyester caps on the surface were first developed in order to manipulate the smart intracellular release of anticancer drugs. first, poly(ethylene glycol)-b-poly(epsilon-caprolactone) (peg-pcl) was successfully grafted on the surface of msn via disulfide bonds which could cleave under a reduction environment in tumor cells. the anticancer drug doxorubicin (dox) was encapsulated into the particle pores. the in vitro drug release profile showed that dox release was significantly restricted by the polymer caps at ph 7.4, while it was greatly accelerated upon the addition of gsh. cytotoxicity evaluation showed good biocompatibility with the hybrid particles. fast endocytosis and intracellular dox release were observed by confocal laser scanning microscopy (clsm). the dox-loaded particles exhibited comparable antitumor activity with free dox towards hela cells and showed in a time-dependent manner. this work developed an extensive method of utilizing aliphatic biodegradable polyesters as polymer caps for msn to control drug delivery. the paper might offer a potential option for cancer therapy.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000322725000008
公开日期	2014-04-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50223]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	He HY,Kuang HH,Yan LS,et al. A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps[J]. physical chemistry chemical physics,2013,15(34):14210-14218.
APA	He HY.,Kuang HH.,Yan LS.,Meng FB.,Xie ZG.,...&Huang YB.(2013).A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps.physical chemistry chemical physics,15(34),14210-14218.
MLA	He HY,et al."A reduction-sensitive carrier system using mesoporous silica nanospheres with biodegradable polyester as caps".physical chemistry chemical physics 15.34(2013):14210-14218.