Aptamer-linked biosensor for thrombin based on AuNPs/thionine-graphene nanocomposite | |
Zhang Z ; Luo LQ ; Zhu LM ; Ding YP ; Deng DM ; Wang ZX | |
刊名 | analyst
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2013 | |
卷号 | 138期号:18页码:5365-5370 |
ISSN号 | 0003-2654 |
通讯作者 | luo lq |
中文摘要 | a novel protocol of electrochemical thrombin aptasensor based on a gold nanoparticles/thionine-graphene (aunps/th-g) nanocomposite modified glassy carbon electrode was presented. graphene was non-covalently functionalized by thionine via pi-stacking interaction, and then aunps were electrodeposited onto the th-g surface. the morphology and conductivity of the aunps/th-g nanocomposite were characterized by scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy. the ethanethiol-substituted oligonucleotide probe was immobilized onto the surface of the aunps/th-g nanocomposite to prepare an electrochemical biosensing platform. the aptamer-thrombin reaction was monitored by differential pulse voltammetry. under optimum conditions, the proposed biosensor exhibits high sensitivity and a low detection limit for thrombin determination. the thrombin could be quantified in a wide range of 0.5 to 40 nm and with a low detection limit of 0.093 nm (s/n = 3). |
收录类别 | SCI收录期刊论文 |
语种 | 英语 |
WOS记录号 | WOS:000323115200026 |
公开日期 | 2014-04-16 |
内容类型 | 期刊论文 |
源URL | [http://ir.ciac.jl.cn/handle/322003/50207] ![]() |
专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
推荐引用方式 GB/T 7714 | Zhang Z,Luo LQ,Zhu LM,et al. Aptamer-linked biosensor for thrombin based on AuNPs/thionine-graphene nanocomposite[J]. analyst,2013,138(18):5365-5370. |
APA | Zhang Z,Luo LQ,Zhu LM,Ding YP,Deng DM,&Wang ZX.(2013).Aptamer-linked biosensor for thrombin based on AuNPs/thionine-graphene nanocomposite.analyst,138(18),5365-5370. |
MLA | Zhang Z,et al."Aptamer-linked biosensor for thrombin based on AuNPs/thionine-graphene nanocomposite".analyst 138.18(2013):5365-5370. |
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