A simple and rapid electrochemical strategy for non-invasive, sensitive and specific detection of cancerous cell

	A simple and rapid electrochemical strategy for non-invasive, sensitive and specific detection of cancerous cell
	Xu SL ; Liu JY ; Wang TS ; Li HL ; Miao YQ ; Liu YQ ; Wang J ; Wang EK
刊名	talanta
	2013
卷号	104 页码:122-127
关键词	BIOCOMPATIBLE CONDUCTIVE ARCHITECTURE ESCHERICHIA-COLI O157-H7 FOLATE-BINDING PROTEIN IMPEDANCE SPECTROSCOPY SURFACE CARBOHYDRATE NANOPARTICLES BIOSENSOR IMMOBILIZATION GLYCOPROTEIN IMMUNOSENSOR
ISSN号	0039-9140
通讯作者	liu yq
中文摘要	developing non-invasive, sensitive and specific sensing strategies for cancerous cell detection with simple and low cost instrumentations provide great advantages in cancer research and early diagnosis of diseases. in the present work, gold nanoparticles (au nps) functionalized with recognition components (folic acid) and signal indicator (ferrocene) was designed to fabricate electrochemical cytosensor. the au nps can not only accelerate electron transfer between signal indicator and the underlying electrode but also accumulate more ferrocene on the cytosensor surface to magnify signal for improving detection sensitivity. the surface-tethered folic acid plays a key role in specific binding folate receptor-riched hela cells on the cytosensor surface, resulting in corresponding current signal change measured by differential pulse voltammetry method. a wide detection range from 10 to 10(6) cells/ml with a detection limit as low as 10 cells/ml for cancerous cells was reached in the presence of a large amount of normal ones with fast differential pulse voltammetry measurement. detection of the captured cells can be finished within 1 min. the developed strategy provides a new way for operationally simple, rapid, sensitive and specific detection of cancerous cells. (c) 2012 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000319310900019
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50084]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xu SL,Liu JY,Wang TS,et al. A simple and rapid electrochemical strategy for non-invasive, sensitive and specific detection of cancerous cell[J]. talanta,2013,104:122-127.
APA	Xu SL.,Liu JY.,Wang TS.,Li HL.,Miao YQ.,...&Wang EK.(2013).A simple and rapid electrochemical strategy for non-invasive, sensitive and specific detection of cancerous cell.talanta,104,122-127.
MLA	Xu SL,et al."A simple and rapid electrochemical strategy for non-invasive, sensitive and specific detection of cancerous cell".talanta 104(2013):122-127.