Argon Direct Analysis in Real Time Mass Spectrometry in Conjunction with Makeup Solvents: A Method for Analysis of Labile Compounds

	Argon Direct Analysis in Real Time Mass Spectrometry in Conjunction with Makeup Solvents: A Method for Analysis of Labile Compounds
	Yang HM ; Wan DB ; Song FR ; Liu ZQ ; Liu SY
刊名	analytical chemistry
	2013
卷号	85 期号:3 页码:1305-1309
关键词	OF-FLIGHT ION-SOURCE DART FUNGICIDES VERSATILE
ISSN号	0003-2700
通讯作者	liu sy
中文摘要	helium direct analysis in real time (he-dart) mass spectrometry (ms) analysis of labile compounds usually tends to be challenging because of the occurrence of prominent fragmentation, which obscures the assigning of an ion to an independent species or merely a fragment in a mixture. in the present work, argon dart (ar-dart) ms in conjunction with makeup solvents has been demonstrated to analyze a variety of labile compounds including nucleosides, alkaloids, glucose, and other small molecules. the results presented here confirm that ar-dart can generate significantly less energetic ions than conventional he-dart and is able to produce the intact molecular ions with little or no fragmentation in both positive and negative ion modes. adding a makeup solvent (absolute ethyl alcohol, methanol, fluorobenzene, or acetone) to the argon gas stream at the exit of the dart ion source can result in 1-2 orders of magnitude increase in detection signals. the sensitivity attainable by ar-dart was found to be comparable to that by he-dart. the investigation of influence of solvents improves our understanding of the fundamental desorption and ionization processes in dart. the practical application of this rapid and high throughput method is demonstrated by the successful analysis of a natural product (crude kusnezoff monkshood) extract, demonstrating the great potential in mixture research.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000314676100011
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50050]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Yang HM,Wan DB,Song FR,et al. Argon Direct Analysis in Real Time Mass Spectrometry in Conjunction with Makeup Solvents: A Method for Analysis of Labile Compounds[J]. analytical chemistry,2013,85(3):1305-1309.
APA	Yang HM,Wan DB,Song FR,Liu ZQ,&Liu SY.(2013).Argon Direct Analysis in Real Time Mass Spectrometry in Conjunction with Makeup Solvents: A Method for Analysis of Labile Compounds.analytical chemistry,85(3),1305-1309.
MLA	Yang HM,et al."Argon Direct Analysis in Real Time Mass Spectrometry in Conjunction with Makeup Solvents: A Method for Analysis of Labile Compounds".analytical chemistry 85.3(2013):1305-1309.