Size-Dependent Stability of Water-Solubilized CdTe Quantum Dots and Their Uptake Mechanism by Live HeLa Cells

	Size-Dependent Stability of Water-Solubilized CdTe Quantum Dots and Their Uptake Mechanism by Live HeLa Cells
	Wang TT ; Jiang X
刊名	acs applied materials & interfaces
	2013
卷号	5 期号:4 页码:1190-1196
关键词	IN-VIVO PHOTOCHEMICAL INSTABILITY GOLD NANOPARTICLES CELLULAR UPTAKE SURFACE-CHARGE NANOCRYSTALS TOXICITY CLATHRIN DELIVERY PATHWAY
ISSN号	1944-8244
通讯作者	jiang x
中文摘要	water-solubilized quantum dots have led to a promising application in cellular labeling and biological imaging. the physicochemical properties of water-solubilized quantum dots, particularly in a physiological environment, are strongly dependent on their size. in this paper, we systematically studied the stability of mercaptosuccinic acid-coated cdte quantum dots (msa-qds) of about 2.3 and 5.4 nm diameters in various buffers with different ph values and under laser irradiation by fluorescence spectroscopy. it was found that larger msa-qds showed better stability. size-dependent uptake of msa-qds by living hela cells was further investigated by confocal microscopy. in phosphate buffer solution, the larger msa-qds entered the cells mainly by endocytosis, and part of the smaller ones entered the cells by passive penetration. in cell culture medium, their uptake pathways could be changed due to the changes of their surface properties. the cytotoxicity of smaller and larger msa-qds was significantly decreased due to the adsorption of some biological components in the cell culture medium on the nanoparticles surface.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000315619100003
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50019]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang TT,Jiang X. Size-Dependent Stability of Water-Solubilized CdTe Quantum Dots and Their Uptake Mechanism by Live HeLa Cells[J]. acs applied materials & interfaces,2013,5(4):1190-1196.
APA	Wang TT,&Jiang X.(2013).Size-Dependent Stability of Water-Solubilized CdTe Quantum Dots and Their Uptake Mechanism by Live HeLa Cells.acs applied materials & interfaces,5(4),1190-1196.
MLA	Wang TT,et al."Size-Dependent Stability of Water-Solubilized CdTe Quantum Dots and Their Uptake Mechanism by Live HeLa Cells".acs applied materials & interfaces 5.4(2013):1190-1196.