Screening and determination of potential xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae using ultrafiltration liquid chromatography-mass spectrometry

	Screening and determination of potential xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae using ultrafiltration liquid chromatography-mass spectrometry
	Liu Y ; Liu S ; Liu ZQ
刊名	journal of chromatography b-analytical technologies in the biomedical and life sciences
	2013
卷号	923 页码:48-53
关键词	SELECTIVE INHIBITOR FEBUXOSTAT TMX-67 RENAL IMPAIRMENT NON-PURINE GOUT HYPERURICEMIA ALLOPURINOL MANAGEMENT Y-700 OXIDOREDUCTASE
ISSN号	1570-0232
通讯作者	liu s
中文摘要	xanthine oxidase (xod) inhibitors play an important role in the treatment of gout and many other diseases related to the superoxide anion metabolism. in this study, an ultrafiltration-liquid chromatography-mass spectrometry (uf-lc-ms) method was developed for the screening and identification of potential xod inhibitors from radix salviae miltiorrhizae extract. eleven lipophilic diterpenoid quinines were identified as xod inhibitors from the extract. the relationship between the structure and activity of the detected compounds was estimated on the basis of the uf-lc-ms data. the results demonstrate that the 1,2-naphthoquinone group is necessary for the xod inhibitory activity of the compounds, and that furan and hydroxyl on the alicyclic ring could enhance the activity of the compounds at different levels. these results may explain and support the medical use of the extract of radix s. miltiorrhizae for the prevention and treatment of hyperuricemia and gout. (c) 2013 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000317148400008
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49944]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu Y,Liu S,Liu ZQ. Screening and determination of potential xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae using ultrafiltration liquid chromatography-mass spectrometry[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2013,923:48-53.
APA	Liu Y,Liu S,&Liu ZQ.(2013).Screening and determination of potential xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae using ultrafiltration liquid chromatography-mass spectrometry.journal of chromatography b-analytical technologies in the biomedical and life sciences,923,48-53.
MLA	Liu Y,et al."Screening and determination of potential xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae using ultrafiltration liquid chromatography-mass spectrometry".journal of chromatography b-analytical technologies in the biomedical and life sciences 923(2013):48-53.