The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers

	The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers
	Ren KX ; Cheng YL ; He CL ; Xiao CS ; Li G ; Chen XS
刊名	polymer
	2013
卷号	54 期号:9 页码:2466-2472
关键词	BLOCK-COPOLYMERS ISOTHERMAL CRYSTALLIZATION MOLECULAR-STRUCTURES PEG CRYSTALLIZATION DIBLOCK COPOLYMER FTIR SPECTROSCOPY PEPTIDE POLYPEPTIDES POLYMERIZATION MORPHOLOGY
ISSN号	0032-3861
通讯作者	he cl
中文摘要	the solid state and melt nanoscale structures of a series of poly(ethylene glycol)-block-poly(gamma-alkyl-l-glutamate)s (peg-b-palg) copolymers bearing different alkyl side groups, i.e., n-butyl, n-hexyl, n-octyl, and n-dodecyl, have been investigated in the present work. an interesting effect of alkyl side groups on the secondary conformation of polypeptide block, crystallization of peg segments and morphology of the copolymers was observed. with increasing the length of alkyl side groups or raising the temperature, the predominant secondary structure gradually changed from alpha-helix to beta-sheet conformation. differential scanning calorimetry, wide-angle x-ray diffraction analysis and polarized optical microscopy indicated that the crystallization and morphology of peg segments were markedly restricted by the polypeptide block. therefore, the alkyl side groups not only exhibited significant influence on the conformation of polypeptide block, but also affected the crystallization of peg segments. the secondary structure, crystallization and spherulite morphology of these synthetic biomaterials, which were significantly influenced by alkyl side groups, may play an important role in their physicochemical properties, such as self-assembly, as well as in some biomedical applications. (c) 2013 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000317632900033
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49902]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Ren KX,Cheng YL,He CL,et al. The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers[J]. polymer,2013,54(9):2466-2472.
APA	Ren KX,Cheng YL,He CL,Xiao CS,Li G,&Chen XS.(2013).The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers.polymer,54(9),2466-2472.
MLA	Ren KX,et al."The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers".polymer 54.9(2013):2466-2472.