Microstructure, mechanical properties, in vitro degradation and cytotoxicity evaluations of Mg-1.5Y-1.2Zn-0.44Zr alloys for biodegradable metallic implants

	Microstructure, mechanical properties, in vitro degradation and cytotoxicity evaluations of Mg-1.5Y-1.2Zn-0.44Zr alloys for biodegradable metallic implants
	Fan J ; Qiu X ; Niu XD ; Tian Z ; Sun W ; Liu XJ ; Li YD ; Li WR ; Meng J
刊名	materials science & engineering c-materials for biological applications
	2013
卷号	33 期号:4 页码:2345-2352
关键词	MAGNESIUM ALLOYS MG-ZN ELECTRON-MICROSCOPY VIVO CORROSION BONE BEHAVIOR IONS STRENGTH TITANIUM RELEASE
ISSN号	0928-4931
通讯作者	meng j
中文摘要	mg-1.5y-1.2zn-0.44zr alloys were newly developed as degradable metallic biomaterials. a comprehensive investigation of the microstructure, mechanical properties, in vitro degradation assessments and in vitro cytotoxicity evaluations of the as-cast state, as-heat treated state and as-extruded state alloys was done. the microstructure observations show that the mg-1.5y-1.2zn-0.44zr alloys are mainly composed of the matrix alpha-mg phases and the mg12zny secondary phases (lps structure). the hot extrusion method significantly refined the grains and eliminated the defects of both as-cast and heat treated alloys and thereby contributed to the better mechanical properties and biodegradation resistance. the values of tensile strength and tensile yield strength of the alloy in the as-extruded condition are about 236 and 178 mpa respectively, with an excellent elongation of 28%. meanwhile, the value of compressive strength is about 471 mpa and the value of bending strength is about 501 mpa. the superior bending strength further demonstrates the excellent ductility of the hot extruded alloys. the results of immersion tests and electrochemical measurements in the sbf indicate that a protective film precipitated on the alloy's surface with the extension of degradation. the protective film contains mg(oh)(2) and hydroxyapatite (ha) which can reinforce osteoblast activity and promote good biocompatibility. no significant cytotoxicity towards l-929 cells was detected and the immersion extracts of alloy samples could enhance the cell proliferation with time in the cytotoxicity evaluations, implying that the mg-1.5y-1.2zn-0.44zr alloys have the potential to be used for biomedical applications. (c) 2013 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000317528700066
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49895]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Fan J,Qiu X,Niu XD,et al. Microstructure, mechanical properties, in vitro degradation and cytotoxicity evaluations of Mg-1.5Y-1.2Zn-0.44Zr alloys for biodegradable metallic implants[J]. materials science & engineering c-materials for biological applications,2013,33(4):2345-2352.
APA	Fan J.,Qiu X.,Niu XD.,Tian Z.,Sun W.,...&Meng J.(2013).Microstructure, mechanical properties, in vitro degradation and cytotoxicity evaluations of Mg-1.5Y-1.2Zn-0.44Zr alloys for biodegradable metallic implants.materials science & engineering c-materials for biological applications,33(4),2345-2352.
MLA	Fan J,et al."Microstructure, mechanical properties, in vitro degradation and cytotoxicity evaluations of Mg-1.5Y-1.2Zn-0.44Zr alloys for biodegradable metallic implants".materials science & engineering c-materials for biological applications 33.4(2013):2345-2352.