Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation

	Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation
	Li B ; Li TH ; Chen G ; Li XY ; Yan LS ; Xie ZG ; Jing XB ; Huang YB
刊名	macromolecular bioscience
	2013
卷号	13 期号:7 页码:893-902
关键词	OXYGEN CARRIERS BLOCK-COPOLYMER ENCAPSULATION PARTICLES CARBONATE
ISSN号	1616-5187
通讯作者	li th
中文摘要	amphiphilic triblock copolymers with carbonyl groups located either in the middle segment or in the third side block are synthesized by adjusting feeding sequence of the comonomers. the conjugation of hemoglobin (hb) on the copolymer micelles is realized by condensation reactions of carbonyl with the amino groups of hb, and the gas-binding capacity of hb is well preserved. interestingly, the reassembly behavior of hb-conjugated micelles (hbm) is explored by adjusting the ph. as for triblock copolymers with a carbonyl-functionalized segment as the third block, hb is rearranged into the inner core of micelles when the ph is adjusted close to the isoelectric point of hb. therefore, it may provide a new needed route for fabrication of protein carriers, which is different from the traditional encapsulation technique.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000327814500008
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49751]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li B,Li TH,Chen G,et al. Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation[J]. macromolecular bioscience,2013,13(7):893-902.
APA	Li B.,Li TH.,Chen G.,Li XY.,Yan LS.,...&Huang YB.(2013).Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation.macromolecular bioscience,13(7),893-902.
MLA	Li B,et al."Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation".macromolecular bioscience 13.7(2013):893-902.