Two multinuclear Gd-III macrocyclic complexes as contrast agents with high relaxivity and stability using rigid linkers

	Two multinuclear Gd-III macrocyclic complexes as contrast agents with high relaxivity and stability using rigid linkers
	Zhao GY ; Lu CG ; Li HL ; Xiao YM ; Zhang WW ; Fang XX ; Wang PX ; Fang XX ; Xu JW ; Yang W
刊名	inorganica chimica acta
	2013
卷号	406 页码:146-152
关键词	GADOLINIUM(III) COMPLEX WATER-EXCHANGE O-17 NMR VARIABLE-TEMPERATURE PHYSICOCHEMICAL CHARACTERIZATION PROTON RELAXIVITY MRI NANOPARTICLES LUMINESCENCE DYNAMICS
ISSN号	0020-1693
通讯作者	xu jw
中文摘要	two macrocyclic chelating mri agents (gd-do3a)(3)-tab and (gd-do3a)(2)-dab have been successfully synthesized by appending three and two gd-do3a moieties upon the acetylbenzene derivatives, respectively. the longitudinal relaxivity of (gd-do3a)(3)-tab measured at 20 mhz, 37 degrees c and ph 7.0 is 6.1 mmgd(-1) s(-1), 74% higher than that of the mononuclear clinical agent [gd(dota)(h2o)]. a 30% or 16% increase in relaxivity was observed upon addition of 0.72 mmbovine serum albumin (bsa) or 10-fold of diamagnetic ion la3+. more importantly, the thermodynamic stability and kinetic inertness of (gddo3a)(3)-tab are comparable to or better than that of [gd(dtpa)(h2o)](2). the luminescence lifetime study on the corresponding (eu-do3a)3-tab analog demonstrated that the agent had one inner-sphere water coordinated to the eu3+ center within the complex. the cytotoxicity study indicated that the toxicity of the agent was low with ic50 = 18 mm. in addition, the characterization of its dinuclear analog (gddo3a)(2)-dab has also been investigated. (c) 2013 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000324325200020
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49644]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhao GY,Lu CG,Li HL,et al. Two multinuclear Gd-III macrocyclic complexes as contrast agents with high relaxivity and stability using rigid linkers[J]. inorganica chimica acta,2013,406:146-152.
APA	Zhao GY.,Lu CG.,Li HL.,Xiao YM.,Zhang WW.,...&Yang W.(2013).Two multinuclear Gd-III macrocyclic complexes as contrast agents with high relaxivity and stability using rigid linkers.inorganica chimica acta,406,146-152.
MLA	Zhao GY,et al."Two multinuclear Gd-III macrocyclic complexes as contrast agents with high relaxivity and stability using rigid linkers".inorganica chimica acta 406(2013):146-152.