Redox-Sensitive Shell-Crosslinked Polypeptide-block-Polysaccharide Micelles for Efficient Intracellular Anticancer Drug Delivery

	Redox-Sensitive Shell-Crosslinked Polypeptide-block-Polysaccharide Micelles for Efficient Intracellular Anticancer Drug Delivery
	Zhang AP ; Zhang Z ; Shi FH ; Xiao CS ; Ding JX ; Zhuang XL ; He CL ; Chen L ; Chen XS
刊名	macromolecular bioscience
	2013
卷号	13 期号:9 页码:1249-1258
关键词	BIOMEDICAL APPLICATIONS CANCER-THERAPY POLYMERIC MICELLES BUILDING-BLOCKS RELEASE NANOPARTICLES DOXORUBICIN SYSTEM COPOLYMER FUNCTIONALIZATION
ISSN号	1616-5187
通讯作者	zhuang xl
中文摘要	redox-responsive scms based on amphiphilic pblg-b-dextran with good biocompatibility are synthesized and used for efficient intracellular drug delivery. the molecular structures and scms characteristics are characterized by h-1 nmr, ft-ir, tem, and dls. the hydrodynamic radius of scms increases gradually in pbs due to the cleavage of disulfide bond in micellar shell caused by the presence of gsh. the encapsulation efficiency and release kinetics of dox are investigated. the fastest dox release is observed under intracellular-mimicking reductive environments. an mtt assay demonstrates that dox-loaded scms show higher cellular proliferation inhibition against gsh-oet pretreated hela and hepg2 than that of the non-pretreated and bso-pretreated ones.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000327882700013
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49637]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang AP,Zhang Z,Shi FH,et al. Redox-Sensitive Shell-Crosslinked Polypeptide-block-Polysaccharide Micelles for Efficient Intracellular Anticancer Drug Delivery[J]. macromolecular bioscience,2013,13(9):1249-1258.
APA	Zhang AP.,Zhang Z.,Shi FH.,Xiao CS.,Ding JX.,...&Chen XS.(2013).Redox-Sensitive Shell-Crosslinked Polypeptide-block-Polysaccharide Micelles for Efficient Intracellular Anticancer Drug Delivery.macromolecular bioscience,13(9),1249-1258.
MLA	Zhang AP,et al."Redox-Sensitive Shell-Crosslinked Polypeptide-block-Polysaccharide Micelles for Efficient Intracellular Anticancer Drug Delivery".macromolecular bioscience 13.9(2013):1249-1258.