Multifunctional Up-Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual-Responsive Drug Controlled Release

	Multifunctional Up-Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual-Responsive Drug Controlled Release
	Zhang X ; Yang PP ; Dai YL ; Ma PA ; Li XJ ; Cheng ZY ; Hou ZY ; Kang XJ ; Li CX ; Lin J
刊名	advanced functional materials
	2013
卷号	23 期号:33 页码:4067-4078
关键词	VIVO PHOTODYNAMIC THERAPY DOPED NAYF4 NANOCRYSTALS BIOIMAGING IN-VIVO CONVERSION NANOPARTICLES SILICA NANOPARTICLES MAGNETIC-RESONANCE UPCONVERTING NANOPARTICLES BIOMEDICAL APPLICATIONS PHOTOTHERMAL THERAPY QUANTUM DOTS
ISSN号	1616-301x
通讯作者	zhang x
中文摘要	multifunctional nanocarriers based on the up-conversion luminescent nanoparticles of nayf4:yb3+/er3+ core (ucnps) and thermo/ph-coupling sensitive polymer poly[(n-isopropylacrylamide)-co-(methacrylic acid)] (p(nipam-co-maa)) gated mesoporous silica shell are reported for cancer theranostics, including fluorescence imaging, and for controlled drug release for therapy. the as-synthesized hybrid nanospheres ucnps@msio(2)-p(nipam-co-maa) show bright green up-conversion fluorescence under 980 nm laser excitation and the thermo/ph-sensitive polymer is active as a valve to moderate the diffusion of the embedded drugs in-and-out of the pore channels of the silica container. the anticancer drug doxorubicin hydrochloride (dox) can be absorbed into ucnps@msio(2)-p(nipam-co-maa) nanospheres and the composite drug delivery system (dds) shows a low level of leakage at low temperature/high ph values but significantly enhanced release at higher temperature/lower ph values, exhibiting an apparent thermo/ph controlled on-off drug release pattern. the as-prepared ucnps@msio(2)-p(nipam-co-maa) hybrid nanospheres can be used as bioimaging agents and biomonitors to track the extent of drug release. the reported multifunctional nanocarriers represent a novel and versatile class of platform for simultaneous imaging and stimuli-responsive controlled drug delivery.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000327492300003
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49622]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang X,Yang PP,Dai YL,et al. Multifunctional Up-Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual-Responsive Drug Controlled Release[J]. advanced functional materials,2013,23(33):4067-4078.
APA	Zhang X.,Yang PP.,Dai YL.,Ma PA.,Li XJ.,...&Lin J.(2013).Multifunctional Up-Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual-Responsive Drug Controlled Release.advanced functional materials,23(33),4067-4078.
MLA	Zhang X,et al."Multifunctional Up-Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual-Responsive Drug Controlled Release".advanced functional materials 23.33(2013):4067-4078.