Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes

	Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes
	Liu Z ; Ju EG ; Liu JH ; Du YD ; Li ZQ ; Yuan QH ; Ren JS ; Qu XG
刊名	biomaterials
	2013
卷号	34 期号:30 页码:7444-7452
关键词	RAY COMPUTED-TOMOGRAPHY IN-VIVO BIODISTRIBUTION MESOPOROUS SILICA NANOPARTICLES BISMUTH SULFIDE NANOPARTICLES CONTRAST AGENTS HEMOLYTIC-ACTIVITY QUANTUM DOTS CT NANOCRYSTALS TOXICITY
ISSN号	0142-9612
通讯作者	ren js
中文摘要	nanoparticulate contrast agents have attracted a great deal of attention along with the rapid development of modern medicine. here, a binary contrast agent based on paa modified baybf5:tm nanoparticles for direct visualization of gastrointestinal (gi) tract has been designed and developed via a one-pot solvothermal route. by taking advantages of excellent colloidal stability, low cytotoxicity, and neglectable hemolysis of these well-designed nanoparticles, their feasibility as a multi-modal contrast agent for gi tract was intensively investigated. significant enhancement of contrast efficacy relative to clinical barium meal and iodine-based contrast agent was evaluated via x-ray imaging and ct imaging in vivo. by doping tm3+ ions into these nanoprobes, in vivo nir-nir imaging was then demonstrated. unlike some invasive imaging modalities, non-invasive imaging strategy including x-ray imaging, ct imaging, and ucl imaging for gi tract could extremely reduce the painlessness to patients, effectively facilitate imaging procedure, as well as rationality economize diagnostic time. critical to clinical applications, long-term toxicity of our contrast agent was additionally investigated in detail, indicating their overall safety. based on our results, paa-baybf5:tm nanoparticles were the excellent multi-modal contrast agent to integrate x-ray imaging, ct imaging, and ucl imaging for direct visualization of gi tract with low systemic toxicity. (c) 2013 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000322931900024
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49589]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu Z,Ju EG,Liu JH,et al. Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes[J]. biomaterials,2013,34(30):7444-7452.
APA	Liu Z.,Ju EG.,Liu JH.,Du YD.,Li ZQ.,...&Qu XG.(2013).Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes.biomaterials,34(30),7444-7452.
MLA	Liu Z,et al."Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes".biomaterials 34.30(2013):7444-7452.