Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy

	Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy
	Wang YH ; Wang HG ; Liu DP ; Song SY ; Wang X ; Zhang HJ
刊名	biomaterials
	2013
卷号	34 期号:31 页码:7715-7724
关键词	TARGETED PHOTOTHERMAL THERAPY NEAR-INFRARED ABSORBENCY RARE-EARTH NANOPHOSPHORS IN-VIVO PHOTODYNAMIC THERAPY FLUORESCENT NANOPARTICLES UPCONVERTING NANOPARTICLES NANOCRYSTALS LUMINESCENCE CELLS
ISSN号	0142-9612
通讯作者	zhang hj
中文摘要	theranostics, the integration of diagnostics and therapies, has become a new concept in the battles with various major diseases such as cancer. here, we report a multifunctional nanoplatform, which is developed by covalently grafting core-shell structured upconversion nanoparticles (ucnps) with nanographene oxide (ngo) via bifunctional polyethylene glycol (peg), and then loading phthalocyanine (znpc) on the surface of ngo. the obtained ucnps-ngo/znpc nanocomposites are not only be used as upconversion luminescence (ucl) imaging probes of cells and whole-body animals with high contrast for diagnosis, but also can generate cytotoxic singlet oxygen under light excitation for photodynamic therapy (pdt), as well as rapidly and efficiently convert the 808 nm laser energy into thermal energy for photothermal therapy (ptt). a remarkably improved and synergistic therapeutic effect compared to ptt or pdt alone is obtained, providing high therapeutic efficiency for cancer treatment. therefore, benefiting from the unique multifunctional hybrid nanostructure. ucnps-ngo/znpc nanocomposites developed herein are promising as an integrated theranostic probe for potential ucl image-guided combinatorial pdt/ptt of cancer. (c) 2013 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000323459100016
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49587]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang YH,Wang HG,Liu DP,et al. Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy[J]. biomaterials,2013,34(31):7715-7724.
APA	Wang YH,Wang HG,Liu DP,Song SY,Wang X,&Zhang HJ.(2013).Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy.biomaterials,34(31),7715-7724.
MLA	Wang YH,et al."Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy".biomaterials 34.31(2013):7715-7724.