In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles

	In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles
	Dai YL ; Xiao HH ; Liu JH ; Yuan QH ; Ma PA ; Yang DM ; Li CX ; Cheng ZY ; Hou ZY ; Yang PP ; Lin J
刊名	journal of the american chemical society
	2013
卷号	135 期号:50 页码:18920-18929
关键词	UP-CONVERSION NANOPARTICLES RAY COMPUTED-TOMOGRAPHY PHOTODYNAMIC THERAPY PHOTOTHERMAL THERAPY CONTRAST AGENT LUMINESCENCE DELIVERY NANOCRYSTALS COMPLEX PHASE
ISSN号	0002-7863
通讯作者	ma pa
中文摘要	controlling anticancer drug activity and release on demand is very significant in cancer therapy. the photoactivated platinum(iv) pro-drug is stable in the dark and can be activated by uv light. in this study, we develop a multifunctional drug delivery system combining upconversion luminescence/magnetic resonance/computer tomography trimodality imaging and nir-activated platinum pro-drug delivery. we use the core-shell structured upconversion nanoparticles to convert the absorbed nir light into uv to activate the trans-platinum(iv) pro-drug, trans,trans,trans-[pt(n-3)(2)(nh3)(py)(o2cch2ch2cooh)(2)]. compared with using the uv directly, the nir has a higher tissue penetration depth and is less harmful to health. meanwhile, the upconversion nanoparticles can effectively deliver the platinum(iv) pro-drugs into the cells by endocytosis. the mice treated with pro-drug-conjugated nanoparticles under near-infrared (nir) irradiation demonstrated better inhibition of tumor growth than that under direct uv irradiation. this multifunctional nanocomposite could be used as multimodality bioimaging contrast agents and transducers by converting nir light into uv for control of drug activity in practical cancer therapy.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000328865100039
公开日期	2014-04-14
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49387]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Dai YL,Xiao HH,Liu JH,et al. In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles[J]. journal of the american chemical society,2013,135(50):18920-18929.
APA	Dai YL.,Xiao HH.,Liu JH.,Yuan QH.,Ma PA.,...&Lin J.(2013).In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles.journal of the american chemical society,135(50),18920-18929.
MLA	Dai YL,et al."In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles".journal of the american chemical society 135.50(2013):18920-18929.