Telescope Control System (TCS) becomes more and more complexity, especially the large telescope control system of force actuators for deformed mirror and position actuators for modifiable degrees of mirrors. It is very difficulty to connect thousands of sensors, actuators and controller with wired link. This paper presented a large telescope control system based on wireless smart sensor (WLTCS), connecting wireless sensors and controllers with wireless link, employing the TCP/IP protocol as communication protocol. Polling access can overcome contention and guarantee every sensor to communicate with controller in time; using intelligent control methods when some channels are interfered, multi-hop wireless paths can improve throughput and performance. The analysis and simulation indicate that WLTCS can greatly reduce complex of implementation and improve communication performance.