Synthesis and in Vitro Photocytotoxicity of Coumarin Derivatives for One- and Two-Photon Excited Photodynamic Therapy

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	Synthesis and in Vitro Photocytotoxicity of Coumarin Derivatives for One- and Two-Photon Excited Photodynamic Therapy
	Zou, QL ; Fang, YY ; Zhao, YX ; Zhao, HY ; Wang, Y ; Gu, Y ; Wu, FP
刊名	JOURNAL OF MEDICINAL CHEMISTRY
	2013
卷号	56 期号:13 页码:5288
ISSN号	0022-2623
通讯作者	Zhao, YX (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China.
中文摘要	Triethylene glycol functionalized coumarin derivatives 1-5 were synthesized and investigated as photosensitizers for one- and two-photon excited photodynamic therapy (PDT). Their absorption, fluorescence, triplet-state quantum yields, and singlet oxygen quantum yields were found to be significantly related to the substituent at the 7-position of the coumarin ring. In vitro photocytotoxicity of these derivatives toward HepG2 cells was examined and compared with a clinical drug. In vitro generation of reactive oxygen species (ROS), cellular uptake, and intracellular distribution of these derivatives were also characterized to fully reveal their structure-property relationships. The results showed that derivative 5, with a two-photon absorption cross section value of 1556 GM, could be a powerful PDT agent for both superficial diseases and solid tumors.
资助信息	National Natural Science Foundation of China [60978057]
语种	英语
公开日期	2014-01-17
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/57539]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Zou, QL,Fang, YY,Zhao, YX,et al. Synthesis and in Vitro Photocytotoxicity of Coumarin Derivatives for One- and Two-Photon Excited Photodynamic Therapy[J]. JOURNAL OF MEDICINAL CHEMISTRY,2013,56(13):5288.
APA	Zou, QL.,Fang, YY.,Zhao, YX.,Zhao, HY.,Wang, Y.,...&Wu, FP.(2013).Synthesis and in Vitro Photocytotoxicity of Coumarin Derivatives for One- and Two-Photon Excited Photodynamic Therapy.JOURNAL OF MEDICINAL CHEMISTRY,56(13),5288.
MLA	Zou, QL,et al."Synthesis and in Vitro Photocytotoxicity of Coumarin Derivatives for One- and Two-Photon Excited Photodynamic Therapy".JOURNAL OF MEDICINAL CHEMISTRY 56.13(2013):5288.