Synthesis and in Vitro Photocytotoxicity of Coumarin Derivatives for One- and Two-Photon Excited Photodynamic Therapy | |
Zou, QL ; Fang, YY ; Zhao, YX ; Zhao, HY ; Wang, Y ; Gu, Y ; Wu, FP | |
刊名 | JOURNAL OF MEDICINAL CHEMISTRY
![]() |
2013 | |
卷号 | 56期号:13页码:5288 |
ISSN号 | 0022-2623 |
通讯作者 | Zhao, YX (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China. |
中文摘要 | Triethylene glycol functionalized coumarin derivatives 1-5 were synthesized and investigated as photosensitizers for one- and two-photon excited photodynamic therapy (PDT). Their absorption, fluorescence, triplet-state quantum yields, and singlet oxygen quantum yields were found to be significantly related to the substituent at the 7-position of the coumarin ring. In vitro photocytotoxicity of these derivatives toward HepG2 cells was examined and compared with a clinical drug. In vitro generation of reactive oxygen species (ROS), cellular uptake, and intracellular distribution of these derivatives were also characterized to fully reveal their structure-property relationships. The results showed that derivative 5, with a two-photon absorption cross section value of 1556 GM, could be a powerful PDT agent for both superficial diseases and solid tumors. |
资助信息 | National Natural Science Foundation of China [60978057] |
语种 | 英语 |
公开日期 | 2014-01-17 |
内容类型 | 期刊论文 |
源URL | [http://ir.iphy.ac.cn/handle/311004/57539] ![]() |
专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
推荐引用方式 GB/T 7714 | Zou, QL,Fang, YY,Zhao, YX,et al. Synthesis and in Vitro Photocytotoxicity of Coumarin Derivatives for One- and Two-Photon Excited Photodynamic Therapy[J]. JOURNAL OF MEDICINAL CHEMISTRY,2013,56(13):5288. |
APA | Zou, QL.,Fang, YY.,Zhao, YX.,Zhao, HY.,Wang, Y.,...&Wu, FP.(2013).Synthesis and in Vitro Photocytotoxicity of Coumarin Derivatives for One- and Two-Photon Excited Photodynamic Therapy.JOURNAL OF MEDICINAL CHEMISTRY,56(13),5288. |
MLA | Zou, QL,et al."Synthesis and in Vitro Photocytotoxicity of Coumarin Derivatives for One- and Two-Photon Excited Photodynamic Therapy".JOURNAL OF MEDICINAL CHEMISTRY 56.13(2013):5288. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论