Small angle X-ray scattering study of the influence of temperature on the structure of DNA/lipid complexes

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	Small angle X-ray scattering study of the influence of temperature on the structure of DNA/lipid complexes
	Hu, SX ; Li, DP ; Mai, ZH ; Li, M
刊名	HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION
	2005
卷号	29 页码:4
关键词	LIPID-DNA COMPLEXES GENE DELIVERY
ISSN号	0254-3052
通讯作者	Hu, SX (reprint author), Chinese Acad Sci, Inst Phys, POB 603, Beijing 100080, Peoples R China.
中文摘要	We report on the synchrotron small-angle X-ray scattering (SAXS) study of self-assembled complex formed by mixing short-chain DNAs with cationic phospholipids in water. The DNA/lipid complex is a sandwiched structure, consisting of alternate layers of DNAs and lipid bilayers with a periodicity of d(D/L). The DNAs at the interfaces are one-dimensionally ordered with a periodicity of d(DNA). When the temperature of the system is increased, the lipid bilayers become soft so that the DNAs are trapped more deeply inside the lipid bilayers. This explains why the measured d(D/L) decreases insignificantly with the increase of temperature. On the other hand, the value of dDNA keeps constant because of the stiffness of the DNAs.
收录类别	SCI
语种	中文
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/52708]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Hu, SX,Li, DP,Mai, ZH,et al. Small angle X-ray scattering study of the influence of temperature on the structure of DNA/lipid complexes[J]. HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION,2005,29:4.
APA	Hu, SX,Li, DP,Mai, ZH,&Li, M.(2005).Small angle X-ray scattering study of the influence of temperature on the structure of DNA/lipid complexes.HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION,29,4.
MLA	Hu, SX,et al."Small angle X-ray scattering study of the influence of temperature on the structure of DNA/lipid complexes".HIGH ENERGY PHYSICS AND NUCLEAR PHYSICS-CHINESE EDITION 29(2005):4.