The trispectrum in ghost inflation

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	The trispectrum in ghost inflation
	Huang, QG
刊名	JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS
	2010
期号	7
关键词	LARGE NON-GAUSSIANITY MULTI-BRID INFLATION
ISSN号	1475-7516
通讯作者	Huang, QG (reprint author), Chinese Acad Sci, KITPC, Key Lab Frontiers Theoret Phys, Inst Theoret Phys, Beijing 100190, Peoples R China.
中文摘要	DNA topoisomerase II is a homodimeric molecular machine that uses ATP hydrolysis to untangle DNA by passing one double-stranded DNA duplex (T-segment) through another double-stranded duplex (G-segment). However, despite extensive studies, the dynamics of ATP-dependent T-transport is still not very clear. Here, based on the proposal that transport of the T-segment through the transiently cleaved G-segment and the opened C-gate of the enzyme is via a free diffusion mechanism, the dynamics of T-transport are studied theoretically. Our results show that, to complete passage of the strand with nearly 100% efficiency, the C-gate is required to open by a width that is only slightly larger than the width of DNA duplex and for a time shorter than 100 mu s in the presence of several k (B) T binding affinities of the T-segment for the B' domains. The results are implied by our understanding of the opening and closing dynamics of the C-gate. Moreover, the dependence of chemomechanical coupling efficiency on degrees of DNA supercoiling by gyrases can also be explained by using our results. On the basis of these theoretical results and previous experimental data, a modified two-gate model for chemomechanical coupling of the topoisomerase II enzyme is proposed.
收录类别	SCI
资助信息	Chinese Academy of Science
语种	英语
公开日期	2013-09-23
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/45589]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Huang, QG. The trispectrum in ghost inflation[J]. JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS,2010(7).
APA	Huang, QG.(2010).The trispectrum in ghost inflation.JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS(7).
MLA	Huang, QG."The trispectrum in ghost inflation".JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS .7(2010).