Label-free monitoring of interaction between DNA and oxaliplatin in aqueous solution by terahertz spectroscopy

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	Label-free monitoring of interaction between DNA and oxaliplatin in aqueous solution by terahertz spectroscopy
	Wu, XJ ; E, YW ; Xu, XL ; Wang, L
刊名	APPLIED PHYSICS LETTERS
	2012
卷号	101 期号:3
关键词	TIME-DOMAIN SPECTROSCOPY THZ MODES
ISSN号	0003-6951
通讯作者	Wang, L: Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China.
中文摘要	We demonstrated the feasibility of applying terahertz time-domain spectroscopy (THz-TDS) to monitor the molecular reactions in aqueous solutions of anticancer drug oxaliplatin with k-DNA and macrophages DNA. The reaction time dependent refractive index and absorption coefficient were extracted and analyzed. The reaction half-decaying time of about 4.0 h for k-DNA and 12.9 h for M-DNA was established. The results suggest that the THz-TDS detection could be an effective label-free technique to sense the molecular reaction in aqueous solutions and could be very useful in biology, medicine, and pharmacy industry. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4737401]
收录类别	SCI
资助信息	National Natural Science Foundation of China [10834015, 61077082]
语种	英语
公开日期	2013-09-18
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/40536]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Wu, XJ,E, YW,Xu, XL,et al. Label-free monitoring of interaction between DNA and oxaliplatin in aqueous solution by terahertz spectroscopy[J]. APPLIED PHYSICS LETTERS,2012,101(3).
APA	Wu, XJ,E, YW,Xu, XL,&Wang, L.(2012).Label-free monitoring of interaction between DNA and oxaliplatin in aqueous solution by terahertz spectroscopy.APPLIED PHYSICS LETTERS,101(3).
MLA	Wu, XJ,et al."Label-free monitoring of interaction between DNA and oxaliplatin in aqueous solution by terahertz spectroscopy".APPLIED PHYSICS LETTERS 101.3(2012).