Label-free monitoring of interaction between DNA and oxaliplatin in aqueous solution by terahertz spectroscopy | |
Wu, XJ ; E, YW ; Xu, XL ; Wang, L | |
刊名 | APPLIED PHYSICS LETTERS
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2012 | |
卷号 | 101期号:3 |
关键词 | TIME-DOMAIN SPECTROSCOPY THZ MODES |
ISSN号 | 0003-6951 |
通讯作者 | Wang, L: Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China. |
中文摘要 | We demonstrated the feasibility of applying terahertz time-domain spectroscopy (THz-TDS) to monitor the molecular reactions in aqueous solutions of anticancer drug oxaliplatin with k-DNA and macrophages DNA. The reaction time dependent refractive index and absorption coefficient were extracted and analyzed. The reaction half-decaying time of about 4.0 h for k-DNA and 12.9 h for M-DNA was established. The results suggest that the THz-TDS detection could be an effective label-free technique to sense the molecular reaction in aqueous solutions and could be very useful in biology, medicine, and pharmacy industry. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4737401] |
收录类别 | SCI |
资助信息 | National Natural Science Foundation of China [10834015, 61077082] |
语种 | 英语 |
公开日期 | 2013-09-18 |
内容类型 | 期刊论文 |
源URL | [http://ir.iphy.ac.cn/handle/311004/40536] ![]() |
专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
推荐引用方式 GB/T 7714 | Wu, XJ,E, YW,Xu, XL,et al. Label-free monitoring of interaction between DNA and oxaliplatin in aqueous solution by terahertz spectroscopy[J]. APPLIED PHYSICS LETTERS,2012,101(3). |
APA | Wu, XJ,E, YW,Xu, XL,&Wang, L.(2012).Label-free monitoring of interaction between DNA and oxaliplatin in aqueous solution by terahertz spectroscopy.APPLIED PHYSICS LETTERS,101(3). |
MLA | Wu, XJ,et al."Label-free monitoring of interaction between DNA and oxaliplatin in aqueous solution by terahertz spectroscopy".APPLIED PHYSICS LETTERS 101.3(2012). |
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