Electrospun aligned nanofibrous composite of MWCNT/polyurethane to enhance vascular endothelium cells proliferation and function

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	Electrospun aligned nanofibrous composite of MWCNT/polyurethane to enhance vascular endothelium cells proliferation and function
	Meng, J ; Han, ZZ ; Kong, H ; Qi, XJ ; Wang, CY ; Xie, SS ; Xu, HY
刊名	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
	2010
卷号	95A 期号:1 页码:312
关键词	WALLED CARBON NANOTUBES TISSUE-ENGINEERING APPLICATIONS ACTIN STRESS FIBERS MECHANICAL-PROPERTIES SCAFFOLDS GROWTH MICE FABRICATION GRAFTS BIOCOMPATIBILITY
ISSN号	1549-3296
通讯作者	Xu, HY: Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China.
中文摘要	Aligned or random nanofibrous meshes of multiwalled carbon nanotubes/polyurethane composite (MWCNT/PU) were fabricated by electrospinning and characterized by scanning electron microscopy (SEM). The regulatory effects of nanofibrous structure and MWCNT on the growth and anticoagulant function of human umbilical vein endothelial cells (HUVECs) were investigated by examining proliferation, type IV collagen secretion, tissue factor and plasminogen activator inhibitor-1 (PAI-1) release, and cytoskeleton arrangement, as well as via pull-down analysis. We show that aligned nanofibrous structure and MWCNT can function as extracellular signals to stimulate cell growth, proliferation, and extracellular collagen secretion, in addition to preserving anticoagulant function. The nanofibrous structures played important roles in the activation of Rac and Cdc42, while CNT regulated the activation of Rho. These two features synergistically activated Rho GTPases that transmitted cell-substrate signals to the cytoplasm. These signals were then relayed to the nucleus by the MAP kinase pathway to direct cytoskeletal arrangement and cell orientation. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 95A: 312-320, 2010.
收录类别	SCI
资助信息	National Natural Science Foundation of China [30970710, 90606018]
语种	英语
公开日期	2013-09-17
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/37263]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Meng, J,Han, ZZ,Kong, H,et al. Electrospun aligned nanofibrous composite of MWCNT/polyurethane to enhance vascular endothelium cells proliferation and function[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2010,95A(1):312.
APA	Meng, J.,Han, ZZ.,Kong, H.,Qi, XJ.,Wang, CY.,...&Xu, HY.(2010).Electrospun aligned nanofibrous composite of MWCNT/polyurethane to enhance vascular endothelium cells proliferation and function.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,95A(1),312.
MLA	Meng, J,et al."Electrospun aligned nanofibrous composite of MWCNT/polyurethane to enhance vascular endothelium cells proliferation and function".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 95A.1(2010):312.