Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells

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	Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells
	Li, CX ; Chen, XF ; Wang, PY ; Wang, WC
刊名	CHINESE PHYSICS LETTERS
	2010
卷号	27 期号:2
关键词	ACTIVATED CALCIUM-CHANNEL OSCILLATIONS MODEL SENSOR STORE STIM1
ISSN号	0256-307X
通讯作者	Wang, WC: Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Lab Soft Matter Phys, Beijing 100190, Peoples R China.
中文摘要	A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2+ dynamics under the effects of Ca2+-release activated Ca2+ (CRAC) channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2+ oscillation and dynamic patterns of Ca2+ wave on the influx rate through the CRAC channel (k(soc)). When k(soc) is small, cytoplasmic Ca2+ is modulated as a frequency-modulation (FM) signal, whereas it shows an amplitude modulation (AM) mode after k(soc) passes through a critical value. The heterogeneity in spatial Ca2+ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2+ spike, a more sustained cytoplasmic Ca2+ gradient is maintained in the AM mode rather than in the FM mode.
收录类别	SCI
语种	英语
公开日期	2013-09-17
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/36687]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Li, CX,Chen, XF,Wang, PY,et al. Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells[J]. CHINESE PHYSICS LETTERS,2010,27(2).
APA	Li, CX,Chen, XF,Wang, PY,&Wang, WC.(2010).Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells.CHINESE PHYSICS LETTERS,27(2).
MLA	Li, CX,et al."Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells".CHINESE PHYSICS LETTERS 27.2(2010).