Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis
	Dong, Fa-Wu 1,2; Fan, Wei-Wei 1; Xu, Feng-Qing 1; Wan, Qin-Li 1; Su, Jia 1; Li, Yan1 ; Zhou, Lu 1; Zhou, Jun1 ; Hu, Jiang-Miao1
刊名	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
	2013-12-01
卷号	15 期号:12 页码:1256-1264
关键词	Pholidota yunnanensis Orchidaceae stilbenoids RAW 264 7 macrophages nitric oxide
ISSN号	1028-6020
通讯作者	Zhou,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China. ; hujiangmiao@mail.kib.ac.cn
英文摘要	Three new stilbenoids, 1-(4-hydroxybenzyl)-imbricatin (1), (E)-4-hydroxy-2,3,3,5-tetramethoxystilbene (2), and (E)-3,4-dihydroxy-2,6-bis(4-hydroxybenzyl)-2,3,5-trimethoxystilbene (3), together with 15 known stilbene derivatives, were isolated from Pholidota yunnanensis. Their structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Furthermore, the inhibitory activities on nitric oxide (NO) production of the isolated compounds were examined in murine macrophages (RAW 264.7) activated by lipopolysaccharide. The cytotoxicity of 18 compounds was determined by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. Among the tested compounds, eight stilbenoids, including three dihydrophenanthrenes, three stilbenes, and one bibenzyl derivative showed inhibitory effects on NO production without cytotoxicity with IC50 values ranging from 4.07 to 7.77M, as compared to MG-132, which was used as a positive control (IC50 of 0.10M). One dihydrophenanthrene, phoyunnanin C (5), showed cytotoxic effects at the test concentrations.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]	ORCHID ; 9,10-DIHYDROPHENANTHRENE ; PHENANTHRENE ; BIBENZYLS
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000328317400006
公开日期	2014-01-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17454]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Dong, Fa-Wu,Fan, Wei-Wei,Xu, Feng-Qing,et al. Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(12):1256-1264.
APA	Dong, Fa-Wu.,Fan, Wei-Wei.,Xu, Feng-Qing.,Wan, Qin-Li.,Su, Jia.,...&Hu, Jiang-Miao.(2013).Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,15(12),1256-1264.
MLA	Dong, Fa-Wu,et al."Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 15.12(2013):1256-1264.