A multitechnique study of europium decatungstate and human serum albumin molecular interaction

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	A multitechnique study of europium decatungstate and human serum albumin molecular interaction
	Zheng, Li 2,4; Ma, Ying 2; Zhang, Guangjin 1; Yao, Jiannian 2; Keita, Bineta 3; Nadjo, Louis 3
刊名	PHYSICAL CHEMISTRY CHEMICAL PHYSICS
	2010
卷号	12 期号:6 页码:1299-1304
关键词	HETEROPOLYTUNGSTATE COMPLEXES QUANTUM DOTS POLYOXOMETALATE ELEMENTS
ISSN号	1463-9076
通讯作者	Zhang, GJ
英文摘要	Polyoxometalates (POMs) show promising biological activities, but the mechanism of these potential therapeutic effects remains to be elucidated at a molecular level. As a step in this direction, the interaction between the Eu-containing decatungstate [EuW(10)O(36)](9-) and human serum albumin (HSA) has been studied by several techniques. Fluorescence/luminescence analysis showed the existence of a strong interaction between the POM and HSA. This interaction has key effects both on luminescence of the POM and on the behaviours of HSA. An enhancement of the POM luminescence is observed upon interaction. The presence of increasing concentrations of the POM results in the progressive quenching of the fluorescence of the single tryptophan of HSA. Circular dichroism led to the conclusion that the binding of the POM did not alter the secondary structure of HSA. Isothermal titration calorimetry revealed an enthalpy-driven binding reaction between HSA and the POM, resulting in the formation of a 1 : 1 complex. The present work is meaningful in finding novel solid state bio-image or fluorescence/luminescence labelling agents.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
研究领域[WOS]	Chemistry ; Physics
关键词[WOS]	HETEROPOLYTUNGSTATE COMPLEXES ; QUANTUM DOTS ; POLYOXOMETALATE ; ELEMENTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000274072900009
公开日期	2013-11-28
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/6256]
专题	过程工程研究所_湿法冶金清洁生产技术国家工程实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Photochem, Inst Chem, Beijing 100190, Peoples R China 3.Univ Paris 11, CNRS, UMR 8000, Chim Phys Lab, F-91405 Orsay, France 4.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Li,Ma, Ying,Zhang, Guangjin,et al. A multitechnique study of europium decatungstate and human serum albumin molecular interaction[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2010,12(6):1299-1304.
APA	Zheng, Li,Ma, Ying,Zhang, Guangjin,Yao, Jiannian,Keita, Bineta,&Nadjo, Louis.(2010).A multitechnique study of europium decatungstate and human serum albumin molecular interaction.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,12(6),1299-1304.
MLA	Zheng, Li,et al."A multitechnique study of europium decatungstate and human serum albumin molecular interaction".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 12.6(2010):1299-1304.