Characterization of Singapore grouper iridovirus (SGIV) ORF086R, a putative homolog of ICP18 involved in cell growth control and virus replication

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Characterization of Singapore grouper iridovirus (SGIV) ORF086R, a putative homolog of ICP18 involved in cell growth control and virus replication
	Xia, LQ ; Cao, JH ; Huang, XH ; Qin, QW
刊名	ARCHIVES OF VIROLOGY
	2009
卷号	154 期号:9 页码:1409-1416
ISSN号	0304-8608
通讯作者	lssqinqw@mail.sysu.edu.cn
中文摘要	Singapore grouper iridovirus (SGIV), as a causative agent of serious systemic disease, causes significant economic losses in grouper aquaculture. In this study, a novel ICP18 homolog encoded by SGIV ORF086R was identified and characterized. Strikingly, ICP18 homologs can be found in all ranaviruses, but not in other sequenced large DNA viruses. SGIV ICP18 is an immediate-early gene and begins to be transcribed as early as 2 h post-infection (p.i.). Western blotting indicated that SGIV ICP18 is translated as early as 6 h p.i. and is a viral non-envelope protein. Subcellular localization analysis revealed that the SGIV ICP18 displays a finely punctate cytoplasmic pattern. Furthermore, overexpression of SGIV ICP18 can promote the growth of grouper embryonic cells (GP) and contribute to SGIV replication. These results should offer important insights into the pathogenesis of ranaviruses.
学科主题	Virology
收录类别	SCI
原文出处	SPRINGER WIEN
WOS记录号	WOS:000269878900004
公开日期	2011-07-03
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/5072]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Xia, LQ,Cao, JH,Huang, XH,et al. Characterization of Singapore grouper iridovirus (SGIV) ORF086R, a putative homolog of ICP18 involved in cell growth control and virus replication[J]. ARCHIVES OF VIROLOGY,2009,154(9):1409-1416.
APA	Xia, LQ,Cao, JH,Huang, XH,&Qin, QW.(2009).Characterization of Singapore grouper iridovirus (SGIV) ORF086R, a putative homolog of ICP18 involved in cell growth control and virus replication.ARCHIVES OF VIROLOGY,154(9),1409-1416.
MLA	Xia, LQ,et al."Characterization of Singapore grouper iridovirus (SGIV) ORF086R, a putative homolog of ICP18 involved in cell growth control and virus replication".ARCHIVES OF VIROLOGY 154.9(2009):1409-1416.