Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides

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	Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides
	Xiao B(肖斌)1,2,3; Liu ZJ(刘照静)1; Liu L(刘磊)2,3; Fu Y(傅尧)1
刊名	Journal of the American Chemical Society
	2013
卷号	135 期号:2 页码:616-619
ISSN号	0002-7863
通讯作者	傅尧
英文摘要	An unexpected C-H activation/C-C cross-coupling reaction has been found to occur between pyridine N-oxides and general nonactivated secondary and even tertiary alkyl bromides. It provides a practically useful approach for the synthesis of alkylated pyridine derivatives. Experimental observations indicated that the C-Br cleavage step involves a radical-type process. Thus, the title reaction provides a rather extraordinary example of Pd-catalyzed cross-coupling of secondary and tertiary aliphatic electrophiles.
学科主题	物理化学与绿色催化
收录类别	SCI
资助信息	the 973 Program (2013CB932800);the NNSFC (20972148);CAS (KJCX2-EW-J02);the China Postdoctoral Science Foundation (2011M500289;2012T50078)
语种	英语
WOS记录号	WOS:000313920800023
公开日期	2013-12-24
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/4885]
专题	兰州化学物理研究所_OSSO国家重点实验室
作者单位	1.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Xiao B,Liu ZJ,Liu L,et al. Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides[J]. Journal of the American Chemical Society,2013,135(2):616-619.
APA	Xiao B,Liu ZJ,Liu L,&Fu Y.(2013).Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides.Journal of the American Chemical Society,135(2),616-619.
MLA	Xiao B,et al."Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides".Journal of the American Chemical Society 135.2(2013):616-619.