Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis
	Ren HX(任海霞)1,2 ; Wang LC(王立成)1 ; Wang XS(王旭生)1 ; Liu X(刘霞)1 ; Jiang SX(蒋生祥)1 ; Jiang SX(蒋生祥)
刊名	Journal of Pharmaceutical and Biomedical Analysis
	2013
卷号	77 页码:83-87
关键词	Absolute ionic mobility Acidity constant Amino acid Cationic coating Hydrodynamic radius
ISSN号	0731-7085
通讯作者	蒋生祥
英文摘要	The ionization constant (pK_a) and limiting ionic mobility of 3-chlorotyrosine (CT) and 3-nitrotyrosine (NT) were determined in capillary zone electrophoresis (CZE) in a wide pH range. Measurements were carried out in a poly(ionic liquid) (PIL) modified capillary at a low pH (1.80–4.00) and a bare fused capillary at an upper pH (3.00–11.00). Electrostatic interaction between analytes and inner wall was suppressed dramatically. Furthermore, parameters usually empirically assumed were calculated from a simple theoretical model. Besides pK_a and limiting ionic mobility, diameter of the hydrated ion was calculated as well. The former were inserted into the database of Peakmaster software, whose predictions led to satisfactory agreement with experimental runs.
学科主题	分析化学与药物化学
收录类别	SCI
资助信息	Natural Science Foundation of Gansu Province, China (No. 0803RJZ017);the National Science Foundation of China (Nos. 21175143;201105107)
语种	英语
WOS记录号	WOS:000316306000014
公开日期	2013-12-10
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/4620]
专题	兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
通讯作者	Jiang SX(蒋生祥)
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Nat Med Gansu Prov, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ren HX,Wang LC,Wang XS,et al. Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis[J]. Journal of Pharmaceutical and Biomedical Analysis,2013,77:83-87.
APA	Ren HX,Wang LC,Wang XS,Liu X,Jiang SX,&蒋生祥.(2013).Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis.Journal of Pharmaceutical and Biomedical Analysis,77,83-87.
MLA	Ren HX,et al."Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis".Journal of Pharmaceutical and Biomedical Analysis 77(2013):83-87.