Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study

doi:10.1016/j.biopsych.2023.12.019

	Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study
	Zhi, Dongmei 10; Jiang, Rongtao 9; Pearlson, Godfrey 8; Fu, Zening 6,7; Qi, Shile 5; Yan, Weizheng 4; Feng, Aichen 1,2,3; Xu, Ming 1,2,3; Calhoun, Vince 6,7; Sui, Jing 6,7,10
刊名	BIOLOGICAL PSYCHIATRY
	2024-05-01
卷号	95 期号:9 页码:828-838
ISSN号	0006-3223
DOI	10.1016/j.biopsych.2023.12.019
通讯作者	Calhoun, Vince(vince.calhoun@ece.gatech.edu) ; Sui, Jing(kittysj@gmail.com)
英文摘要	BACKGROUND: Environmental exposures play a crucial role in shaping children's behavioral development. However, the mechanisms by which these exposures interact with brain functional connectivity and influence behavior remain unexplored. METHODS: We investigated the comprehensive environment-brain-behavior triple interactions through rigorous association, prediction, and mediation analyses, while adjusting for multiple confounders. Particularly, we examined the predictive power of brain functional network connectivity (FNC) and 41 environmental exposures for 23 behaviors related to cognitive ability and mental health in 7655 children selected from the Adolescent Brain Cognitive Development (ABCD) Study at both baseline and follow-up. RESULTS: FNC demonstrated more predictability for cognitive abilities than for mental health, with cross-validation from the UK Biobank study (N = 20,852), highlighting the importance of thalamus and hippocampus in longitudinal prediction, while FNC1environment demonstrated more predictive power than FNC in both cross-sectional and longitudinal prediction of all behaviors, especially for mental health (r = 0.32-0.63). We found that family and neighborhood exposures were common critical environmental influencers on cognitive ability and mental health, which can be mediated by FNC significantly. Healthy perinatal development was a unique protective factor for higher cognitive ability, whereas sleep problems, family conflicts, and adverse school environments specifically increased risk of poor mental health. CONCLUSIONS: This work revealed comprehensive environment-brain-behavior triple interactions based on the ABCD Study, identified cognitive control and default mode networks as the most predictive functional networks for a wide repertoire of behaviors, and underscored the long-lasting impact of critical environmental exposures on childhood development, in which sleep problems were the most prominent factors affecting mental health.
资助项目	Scientific and Technological Innovation 2030 grant[2021ZD0200500] ; Natural Science Foundation of China[62373062] ; Natural Science Foundation of China[82022035] ; China Postdoctoral Science Foundation[2022M710434] ; National Institutes of Health[R01EB005846] ; National Institutes of Health[R01MH117107] ; National Institutes of Health[R01MH118695] ; National Science Foundation[2112455]
WOS关键词	SOCIOECONOMIC-STATUS ; FAMILY INCOME ; CHILDHOOD ; RISK ; ASSOCIATION ; ATTENTION ; PATTERNS ; EXPOSURE
WOS研究方向	Neurosciences & Neurology ; Psychiatry
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:001227269700001
资助机构	Scientific and Technological Innovation 2030 grant ; Natural Science Foundation of China ; China Postdoctoral Science Foundation ; National Institutes of Health ; National Science Foundation
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/58451]
专题	自动化研究所_脑网络组研究中心
通讯作者	Calhoun, Vince; Sui, Jing
作者单位	1.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.NIH, Natl Inst Alcohol Abuse & Alcoholism, Lab Neuroimaging, Bethesda, MD USA 5.Nanjing Univ Aeronaut & Astronaut, Coll Comp Sci & Technol, Nanjing, Peoples R China 6.Georgia State Univ, Atlanta, GA 30302 USA 7.Emory Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30307 USA 8.Yale Sch Med, Dept Psychiat & Neurobiol, New Haven, CT USA 9.Yale Sch Med, Dept Radiol & Biomed Imaging, New Haven, CT USA 10.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhi, Dongmei,Jiang, Rongtao,Pearlson, Godfrey,et al. Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study[J]. BIOLOGICAL PSYCHIATRY,2024,95(9):828-838.
APA	Zhi, Dongmei.,Jiang, Rongtao.,Pearlson, Godfrey.,Fu, Zening.,Qi, Shile.,...&Sui, Jing.(2024).Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study.BIOLOGICAL PSYCHIATRY,95(9),828-838.
MLA	Zhi, Dongmei,et al."Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study".BIOLOGICAL PSYCHIATRY 95.9(2024):828-838.