Wintersweet-like Nanohybrids of Titanium-doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic

doi:10.1002/adhm.202400830

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Wintersweet-like Nanohybrids of Titanium-doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic
	Lu, Qianyun 5,6; Wang, Xiaotong 4; Fan, Xin 5; Lin, Jinguo 3; Hu, Jiayi 5; Duan, Guangxin 4; Yu, Huimin 2; Geng, Zihan 1; Wang, Xingang 6; Dai, Hongliang 6
刊名	ADVANCED HEALTHCARE MATERIALS
	2024-06-16
页码	13
关键词	cerium vanadate chemodynamic therapy polypyrrole reactive oxygen species theranostic
ISSN号	2192-2640
DOI	10.1002/adhm.202400830
通讯作者	Dai, Hongliang(daihongliang@just.edu.cn) ; Liu, Feng(liufeng@imech.ac.cn) ; Wen, Ling(wenling@suda.edu.cn) ; Geng, Hongya(geng.hongya@sz.tsinghua.edu.cn)
英文摘要	Compromises between enhanced on-targeting reactivity and precise real-time monitoring in the tumor microenvironment (TME) are the main roadblocks for catalytic cancer therapy. The hallmark of a high level of hydrogen peroxide (H2O2) and acidic extracellular environment of the hypoxia solid tumor can underpin therapeutic and tracking performance. Herein, this work provides an activatable wintersweet-like nanohybrid consisting of titanium (Ti) doped cerium vanadate nanorods with the modification of polypyrrole (PPy) nanoparticles (CeVO4-Ti@PPy) for combinatorial therapies of breast carcinoma. The Ti dopants in the size-controllable CeVO4 nanorods lower the energy barrier (0.5 eV) of the rate-determining steps and elaborate peroxidase-like (POD-like) activities to improve the generation of toxic hydroxyl radical (OH) according to the density functional theory (DFT) calculation. The multiple enzyme-like activities, including the intrinsic glutathione peroxidase (GPx) and catalase (CAT), achieve a record-high therapeutic efficiency. Coupling this oxidative stress with the photothermal effects of PPy enables enhanced catalytic tumor necrosis. The exterior PPy heterogeneous structure can be further doped with protons in the local acidic environment to intensify photoacoustic signals, allowing the non-invasive accurate tracking of tumors. The theranostic performance displayed negligible attenuated signals in near-infrared (NIR) windows. This organic-inorganic nanohybrid with a heterogeneous structure provides the potential to improve the overall outcomes of catalytic therapy. Enhanced targeting reactivity and precise real-time monitoring are crucial for catalytic cancer therapy. Therefore, an activable organic-inorganic CeVO4-Ti@PPy nanohybrid is proposed, combining multiple simulated enzyme-like activities (chemodynamic therapy) and excellent photothermal effects to enhance catalytic cancer therapy. Additionally, the real-time and non-invasive visualization of tumors using photoacoustic imaging and photothermal imaging, enabling precise targeting therapy and monitoring. image
资助项目	National Natural Science Foundation of China ; Postdoctoral Research Foundation of China[2019M652274] ; Qinglan Project of Jiangsu Province of China[2022] ; Postdoctoral Preferred Funding Project of Jiangxi[2019KY17] ; Scientific Research Foundation from Shenzhen Finance Bureau ; Joint Project of Industry-University-Research of Jiangsu Province[BY2021420] ; Joint Project of Industry-University-Research of Jiangsu Province[202304A0394] ; [51908252] ; [22305141] ; [82172044] ; [11972349] ; [11790292]
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:001247833300001
资助机构	National Natural Science Foundation of China ; Postdoctoral Research Foundation of China ; Qinglan Project of Jiangsu Province of China ; Postdoctoral Preferred Funding Project of Jiangxi ; Scientific Research Foundation from Shenzhen Finance Bureau ; Joint Project of Industry-University-Research of Jiangsu Province
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/95663]
专题	力学研究所_非线性力学国家重点实验室
通讯作者	Dai, Hongliang; Liu, Feng; Wen, Ling; Geng, Hongya
作者单位	1.Tsinghua Univ, Shenzhen Int Grad Sch, Tsinghua Berkeley Shenzhen Inst, Shenzhen 518055, Guangdong, Peoples R China 2.Tsinghua Univ, Ctr Synthet & Syst Biol, Dept Chem Engn, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China 4.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, State Key Lab Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China 5.Tsinghua Univ, Inst Biomed & Hlth Engn, Shenzhen Int Grad Sch, Shenzhen 518055, Guangdong, Peoples R China 6.Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang 212003, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Lu, Qianyun,Wang, Xiaotong,Fan, Xin,et al. Wintersweet-like Nanohybrids of Titanium-doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic[J]. ADVANCED HEALTHCARE MATERIALS,2024:13.
APA	Lu, Qianyun.,Wang, Xiaotong.,Fan, Xin.,Lin, Jinguo.,Hu, Jiayi.,...&Geng, Hongya.(2024).Wintersweet-like Nanohybrids of Titanium-doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic.ADVANCED HEALTHCARE MATERIALS,13.
MLA	Lu, Qianyun,et al."Wintersweet-like Nanohybrids of Titanium-doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic".ADVANCED HEALTHCARE MATERIALS (2024):13.