A novel chitosan antioxidant bearing sulfhydryl group: Synthesis, characterization and activity assessment

doi:10.1016/j.ijbiomac.2024.129816

	A novel chitosan antioxidant bearing sulfhydryl group: Synthesis, characterization and activity assessment
	Han, Xiangru 1,2,3; Mi, Yingqi 1,2,3; Ji, Yuting 1,2,3; Sun, Mingzhi 4; Tang, Hongxia 4; Dong, Fang 1,2,3; Guo, Zhanyong 1,2,3
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2024-03-01
卷号	261 页码:14
关键词	Antioxidant activity Chitosan Quaternary ammonium salt Sulfhydryl group
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2024.129816
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	To improve the antioxidant activity, sulfhydryl groups (-SH) were introduced into chitosan. Acylated chitosan derivatives, chitosan cationic salt derivatives, hydroxypropyl trimethylammonium chloride chitosan quaternary ammonium salt (HACC) derivatives and N,N,N-trimethyl chitosan iodine (TMC) derivatives were obtained. The chitosan derivatives were characterized by FTIR and 1H NMR to confirm the successful synthesis. Ellman's reagent was used to determine that the compound contained free sulfhydryl groups. The water solubility and thermal stability of chitosan and derivatives were evaluated. The antioxidant activities of the derivatives were verified, including DPPH radical scavenging activity, superoxide anion radical scavenging activity and reducing power activity. The novel chitosan derivatives showed excellent antioxidant activities. Toxicity assay used L929 cells proved that the derivatives had no significant toxic. The results showed that the chitosan derivatives bearing sulfhydryl groups described in this paper has a certain antioxidant effect, which provides a practical approach for further study of chitosan.
WOS关键词	REDOX STATE ; IN-VITRO ; DERIVATIVES
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
WOS记录号	WOS:001176852100001
资助机构	Chinese Academy of Sciences, Shandong Key R D Plan ; Major Scientific and Technological Innovation Project ; The 2022 Central Guiding Local Science and Technology Development Fund Project in Shandong Province
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34935]
专题	中国科学院烟台海岸带研究所
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Qingdao Dongheng Zhiyuan Automobile Serv Co LTD, Qingdao 264100, Peoples R China
推荐引用方式 GB/T 7714	Han, Xiangru,Mi, Yingqi,Ji, Yuting,et al. A novel chitosan antioxidant bearing sulfhydryl group: Synthesis, characterization and activity assessment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,261:14.
APA	Han, Xiangru.,Mi, Yingqi.,Ji, Yuting.,Sun, Mingzhi.,Tang, Hongxia.,...&Guo, Zhanyong.(2024).A novel chitosan antioxidant bearing sulfhydryl group: Synthesis, characterization and activity assessment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,261,14.
MLA	Han, Xiangru,et al."A novel chitosan antioxidant bearing sulfhydryl group: Synthesis, characterization and activity assessment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 261(2024):14.