RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte

	RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte
	Xin Huang 1; Cuifang Hao 1; Xiaofang Shen 1; Yuhua Zhang 1; Xiaoyan Liu 1
刊名	Reproductive Biology and Endocrinology
	2013
卷号	11 期号:1
ISSN号	1477-7827
英文摘要	Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. The developmental competence of oocytes and embryos in PCOS patients is reduced to a certain extent (comparing to non-PCOS patients, the high quality embryo rate was decreased by 16% from the data of our centre) during the in vitro fertilization (IVF) process. Cross-talk between the oocyte and cumulus cells is critical for oocyte maturation and embryo competence. In this study, we have evaluated the transcription of specific genes in cumulus cells harvested from pre-ovulatory follicles of PCOS patients before IVF, according to individual oocyte nuclear maturity and developmental competence. Seven genes ( RUNX2 , PSAT1 , ADAMTS9 , CXCL1 , CXCL2 , CXCL3 , and ITGB5 ) were targeted from our previous cDNA microarray data which isolated genes related to oocyte nuclear maturation in PCOS patients. Two additional genes which had been found to be associated with oocyte maturation or embryo quality in non-PCOS patients ( GPX3 and PTX3 ) were also studied.
语种	英语
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34512]
专题	中国科学院烟台海岸带研究所
作者单位	1.黑龙江省环境保护科学研究院 2.Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences
推荐引用方式 GB/T 7714	Xin Huang,Cuifang Hao,Xiaofang Shen,et al. RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte[J]. Reproductive Biology and Endocrinology,2013,11(1).
APA	Xin Huang,Cuifang Hao,Xiaofang Shen,Yuhua Zhang,&Xiaoyan Liu.(2013).RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte.Reproductive Biology and Endocrinology,11(1).
MLA	Xin Huang,et al."RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte".Reproductive Biology and Endocrinology 11.1(2013).