Jujube metabolome selection determined the edible properties acquired during domestication

doi:10.1111/tpj.15617

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	Jujube metabolome selection determined the edible properties acquired during domestication
	Zhang, Zhong ; Shi, Qianqian ; Wang, Bin 2; Ma, Aimin 1; Wang, Yongkang 6; Xue, Qingtun ; Shen, Bingqi ; Hamaila, Halina ; Tang, Tang 2; Qi, Xiaoquan 1
刊名	PLANT JOURNAL
	2022
卷号	109 期号:5 页码:1116-1133
关键词	domestication metabolome genome-wide association study specialized metabolites fruit tree jujube
ISSN号	0960-7412
DOI	10.1111/tpj.15617
文献子类	Article
英文摘要	Plants supply both food and medicinal compounds, which are ascribed to diverse metabolites produced by plants. However, studies on domestication-driven changes in the metabolome and genetic basis of bioactive molecules in perennial fruit trees are generally lacking. Here, we conducted multidimensional analyses revealing a singular domestication event involving the genomic and metabolomic selection of jujube trees (Ziziphus jujuba Mill.). The genomic selection for domesticated genes was highly enriched in metabolic pathways, including carbohydrates and specialized metabolism. Domesticated metabolome profiling indicated that 187 metabolites exhibited significant divergence as a result of directional selection. Malic acid was directly selected during domestication, and the simultaneous selection of specialized metabolites, including triterpenes, consequently lead to edible properties. Cyclopeptide alkaloids (CPAs) were specifically targeted for the divergence between dry and fresh cultivars. We identified 1080 significantly associated loci for 986 metabolites. Among them, 15 triterpenes were directly selected at six major loci, allowing the identification of a homologous cluster containing seven 2,3-oxidosqualene cyclases (OSCs). An OSC gene was found to contribute to the reduction in the content of triterpenes during domestication. The complete pathway for synthesizing ursolic acid was dissected by integration of the metabolome and transcriptome. Additionally, an N-methyltransferase involved in the biosynthesis of CPA and responsible for inter-cultivar content variation was identified. The present study promotes our understanding of the selection process of the global metabolome subsequent to fruit tree domestication and facilitates the genetic manipulation of specialized metabolites to enhance their edible traits.
学科主题	Plant Sciences
电子版国际标准刊号	1365-313X
出版地	HOBOKEN
WOS关键词	OXIDOSQUALENE CYCLASES ; TRITERPENE SYNTHASE ; NATURAL VARIATION ; FRUIT ; BIOSYNTHESIS ; GENOME ; EVOLUTION ; CLONING
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
语种	英语
出版者	WILEY
WOS记录号	WOS:000770103400008
资助机构	National Key Research and Development Program of China [2018YFD1000607] ; National Natural Science Foundation of China [32001343, 32171839] ; Industrial System Program of Xinjiang Uygur Autonomous Region [XJCYTX-01-07-2021] ; Shaanxi Province Science and Technology Innovation Project [2021XYF-11]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/28475]
专题	中科院植物分子生理学重点实验室
作者单位	1.Wuhan Metware Biotechnol Co Ltd, Wuhan 430070, Peoples R China 2.Northwest A&F Univ, Coll Forestry, Res Ctr Jujube Engn & Technol, Key Comprehens Lab Forestry Shaanxi Prov,State Fo, Yangling 712100, Shaanxi, Peoples R China 3.Hainan Univ, Coll Trop Crops, Haikou 572208, Hainan, Peoples R China 4.Fernie, Alisdair R.] Max Planck Inst Mol Plant Physiol, D-14476 Potsdam, Germany 5.Shanxi Acad Agr Sci, Pomol Inst, Taigu 030815, Peoples R China 6.Chinese Acad Sci, Physiol Inst Bot, Key Lab Plant Mol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhong,Shi, Qianqian,Wang, Bin,et al. Jujube metabolome selection determined the edible properties acquired during domestication[J]. PLANT JOURNAL,2022,109(5):1116-1133.
APA	Zhang, Zhong.,Shi, Qianqian.,Wang, Bin.,Ma, Aimin.,Wang, Yongkang.,...&Li, Xingang.(2022).Jujube metabolome selection determined the edible properties acquired during domestication.PLANT JOURNAL,109(5),1116-1133.
MLA	Zhang, Zhong,et al."Jujube metabolome selection determined the edible properties acquired during domestication".PLANT JOURNAL 109.5(2022):1116-1133.