Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency

doi:10.1093/jxb/erac517

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	Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency
	Wang, Tianzuo ; Wang, Jing ; Chen, Li ; Yao, Jiaying 3; Yuan, Zan ; Zhang, Dong ; Zhang, Wen-Hao
刊名	JOURNAL OF EXPERIMENTAL BOTANY
	2023
卷号	74 期号:6 页码:2005-2015
关键词	3D chromatin architecture histone modification hormonal response Medicago truncatula phosphorus deficiency root system architecture transcriptional regulation
ISSN号	0022-0957
DOI	10.1093/jxb/erac517
文献子类	Article
英文摘要	Emerging evidence reveals that the three-dimensional (3D) chromatin architecture plays a key regulatory role in various biological processes of plants. However, information on the 3D chromatin architecture of the legume model plant Medicago truncatula and its potential roles in the regulation of response to mineral nutrient deficiency are very limited. Using high-resolution chromosome conformation capture sequencing, we identified the 3D genome structure of M. truncatula in terms of A/B compartments, topologically associated domains (TADs) and chromatin loops. The gene density, expressional level, and active histone modification were higher in A compartments than in B compartments. Moreover, we analysed the 3D chromatin architecture reorganization in response to phosphorus (P) deficiency. The intra-chromosomal cis-interaction proportion was increased by P deficiency, and a total of 748 A/B compartment switch regions were detected. In these regions, density changes in H3K4me3 and H3K27ac modifications were associated with expression of P deficiency-responsive genes involved in root system architecture and hormonal responses. Furthermore, these genes enhanced P uptake and mobilization by increasing root surface area and strengthening signal transduction under P deficiency. These findings advance our understanding of the potential roles of 3D chromatin architecture in responses of plants in general, and in particular in M. truncatula, to P deficiency. Reorganization of the 3D chromatin architecture is associated with transcriptional regulation to enhance phosphorus uptake and mobilization in Medicago truncatulaunder phosphorus deficiency.
学科主题	Plant Sciences
电子版国际标准刊号	1460-2431
出版地	OXFORD
WOS关键词	3D GENOME ARCHITECTURE ; HI-C ; ARABIDOPSIS ; REVEAL ; TRANSPORTERS ; CONFORMATION ; PRINCIPLES ; CAPTURE ; DOMAINS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000918996900001
资助机构	Science and Technology Innovation 2030-Major Project of China [2022ZD04012] ; National Natural Science Foundation of China [32070351, 31830011] ; Science and Technology Program of Inner Mongolia, China [2021GG0372]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/29086]
专题	植被与环境变化国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, State Key Lab Vegetat & Environm Change, Beijing 100093, Peoples R China 2.Annoroad Gene Technol Beijing Co Ltd, Beijing 100180, Peoples R China 3.Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Tianzuo,Wang, Jing,Chen, Li,et al. Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency[J]. JOURNAL OF EXPERIMENTAL BOTANY,2023,74(6):2005-2015.
APA	Wang, Tianzuo.,Wang, Jing.,Chen, Li.,Yao, Jiaying.,Yuan, Zan.,...&Zhang, Wen-Hao.(2023).Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency.JOURNAL OF EXPERIMENTAL BOTANY,74(6),2005-2015.
MLA	Wang, Tianzuo,et al."Reorganization of three-dimensional chromatin architecture in Medicago truncatula under phosphorus deficiency".JOURNAL OF EXPERIMENTAL BOTANY 74.6(2023):2005-2015.