PHYLOGENETIC EXPLORATION OF TRADITIONAL CHINESE MEDICINAL PLANTS: A CASE STUDY ON LAMIACEAE

doi:10.30848/PJB2022-3(19)

CORC > 植物研究所 > 中国科学院植物研究所 > 系统与进化植物学国家重点实验室

	PHYLOGENETIC EXPLORATION OF TRADITIONAL CHINESE MEDICINAL PLANTS: A CASE STUDY ON LAMIACEAE
	Zaman, Wajid 3; Ye, Jianfei 2; Ahmad, Mushtaq 4; Saqib, Saddam 3; Shinwari, Zabta Khan 4; Chen, Zhiduan 5
刊名	PAKISTAN JOURNAL OF BOTANY
	2022
卷号	54 期号:3 页码:1033-1040
关键词	Bioprospecting Hot nodes Lamiaceae Phylogeny TCM plants
ISSN号	0556-3321
DOI	10.30848/PJB2022-3(19)
文献子类	Article
英文摘要	Lamiaceae (Labiatae) are one of the most important medicinal plant families having a wide variety of plants with traditional medicinal uses. The medicinal species of Lamiaceae are mainly used for musculoskeletal, skin, circulatory and digestive disorders in traditional Chinese medicines (TCMs). The purpose of this study was to provide a phylogenetic exploration of traditionally used medicinal taxa of Lamiaceae as a roadmap to predict potential medicinal plants from this family for future bioprospecting. We collected data of Lamiaceae TCM plants from local pharmacopeias with traditional medicinal uses and phytochemical information. The data were examined through phylogenetic approaches i.e. nearest taxon index (NTI) and net related index (NRI) to find clustering and overdispersion of TCM plants of Lamiaceae. In addition, we used hot node analysis to identify overrepresentation among lineages against different disorders that possess high priority for further phytochemical and pharmacological investigation. The phylogenetic patterns were examined for the traditional uses of 345 species belonging to 77 Lamiaceae genera in nine medicinal categories. Overall, most of the medicinal uses showed clustered structure on the phylogeny of TCM plants of Lamiaceae (NRI and NTI 1). Of all the nine medicinal usage categories, the NRI matrix identified only two significant clusterings with p<0.05 for urinary and reproductive disorders. In total of 488 hot nodes that are significantly overabundant in species are used to treat different disorders. The highest number of hot nodes recovered was 191 for reproductive disorder, of these 138 species were reported to be potential novel species. The majority of new potential species were reported from Ajuga, Elsholtzia and Salvia. These results strongly indicate the independent discovery of plant usages in the light of phylogenetic exploration. We concluded that phylogenetic approaches could focus on screening efforts of taxonomic groups containing traditionally used species with abundant therapeutic compounds for the discovery of alternative/complementary medicines. The phylogeny-based study, after further refinement, will expand the horizon of medicinal plant exploration of plant-based bioactive compounds.
学科主题	Plant Sciences
电子版国际标准刊号	2070-3368
出版地	KARACHI
WOS关键词	DISCOVERY ; FLORAS ; EVOLUTION ; TOOLS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
语种	英语
出版者	PAKISTAN BOTANICAL SOC
WOS记录号	WOS:000765037800029
资助机构	National Natural Science Foundation of China [NNSF 31590822, 31800178] ; Strategic Priority Research Program of CAS [XDA19050103, XDB31000000] ; Sino-Africa Joint Research Center, Chinese Academy of Sciences, CAS International Research and Education Development Program [SAJC201613] ; CAS-TWAS President.s Fellowship for International Ph.D. Students
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/29001]
专题	系统与进化植物学国家重点实验室
作者单位	1.Chinese Acad Sci, Sino Africa Joint Res Ctr, Wuhan 430074, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 4.Chinese Acad Sci, Inst Bot, Beijing Bot Garden, Beijing 100093, Peoples R China 5.Quaid i Azam Univ Islamabad, Dept Plant Sci, Islamabad 45320, Pakistan
推荐引用方式 GB/T 7714	Zaman, Wajid,Ye, Jianfei,Ahmad, Mushtaq,et al. PHYLOGENETIC EXPLORATION OF TRADITIONAL CHINESE MEDICINAL PLANTS: A CASE STUDY ON LAMIACEAE[J]. PAKISTAN JOURNAL OF BOTANY,2022,54(3):1033-1040.
APA	Zaman, Wajid,Ye, Jianfei,Ahmad, Mushtaq,Saqib, Saddam,Shinwari, Zabta Khan,&Chen, Zhiduan.(2022).PHYLOGENETIC EXPLORATION OF TRADITIONAL CHINESE MEDICINAL PLANTS: A CASE STUDY ON LAMIACEAE.PAKISTAN JOURNAL OF BOTANY,54(3),1033-1040.
MLA	Zaman, Wajid,et al."PHYLOGENETIC EXPLORATION OF TRADITIONAL CHINESE MEDICINAL PLANTS: A CASE STUDY ON LAMIACEAE".PAKISTAN JOURNAL OF BOTANY 54.3(2022):1033-1040.