Emestrin-type thiodiketopiperazines from Aspergillus nidulans SD-531, a fungus obtained from the deep-sea sediment of cold seep in the South China Sea

doi:10.1016/j.dsr.2023.104004

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	Emestrin-type thiodiketopiperazines from Aspergillus nidulans SD-531, a fungus obtained from the deep-sea sediment of cold seep in the South China Sea
	Lv, Feng-Yi 4,5; Mandi, Attila 1; Li, Xiao-Ming 4,5; Chi, Lu-Ping 4,5; Li, Xin 4,5; Wang, Bin-Gui 2,4,5,6; Kurtan, Tibor 1,3; Meng, Ling-Hong 2,4,5,6
刊名	DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS
	2023-05-01
卷号	195 页码:7
关键词	Aspergillus nidulans Cold seep fungus Emestrin-type thiodiketopiperazines Antimicrobial activity Cytotoxicity
ISSN号	0967-0637
DOI	10.1016/j.dsr.2023.104004
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Kurtan, Tibor(kurtan.tibor@science.unideb.hu) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn)
英文摘要	Three new emestrin-type thiodiketopiperazines including didethio-11a-methylthioemestrin (1), 7 & PRIME;-epi-didethio-11a-methylthioemestrin (2), and 2 & DPRIME;-desmethyl-MPC1001F (3), along with three known analogues emestrin (4), dethiosecoemestrin (5), and emestrin H (6), were isolated and identified from the culture extract of Aspergillus nidulans SD-531, a fungus obtained from the deep-sea cold seep sediment sample collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analysis and TDDFT-ECD calculations. Compounds 3-6 showed antimicrobial activity against some of the tested strains, while compounds 3-5 had cytotoxic activity against the tumor cell line Huh 7.5. Compound 4 exhibited the strongest cytotoxic activity with an IC50 value of 0.25 & mu;M, which was better than that of the positive control sorafenib.
资助项目	Shandong Special Fund for Qingdao National Laboratory for Marine Science and Technology[2022QNLM030004-4] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA22050401] ; NationalNatural Science Foundation of China[U2006203] ; NationalNatural Science Foundation of China[42076090] ; NationalNatural Science Foundation of China[41976090] ; Chinese Academy of Sciences ; National Research, Development and Innovation Office[K138672] ; National Research, Development and Innovation Office[FK134653] ; Governmental Information-Technology Development Agency
WOS关键词	EPIPOLYTHIODIOXOPIPERAZINES ; METABOLITES ; PRODUCTS
WOS研究方向	Oceanography
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:001029199600001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/182493]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Kurtan, Tibor; Meng, Ling-Hong
作者单位	1.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary 2.Chinese Acad Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Univ Debrecen, Dept Organ Chem, POB 20, H-4010 Debrecen, Hungary 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China 6.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lv, Feng-Yi,Mandi, Attila,Li, Xiao-Ming,et al. Emestrin-type thiodiketopiperazines from Aspergillus nidulans SD-531, a fungus obtained from the deep-sea sediment of cold seep in the South China Sea[J]. DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS,2023,195:7.
APA	Lv, Feng-Yi.,Mandi, Attila.,Li, Xiao-Ming.,Chi, Lu-Ping.,Li, Xin.,...&Meng, Ling-Hong.(2023).Emestrin-type thiodiketopiperazines from Aspergillus nidulans SD-531, a fungus obtained from the deep-sea sediment of cold seep in the South China Sea.DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS,195,7.
MLA	Lv, Feng-Yi,et al."Emestrin-type thiodiketopiperazines from Aspergillus nidulans SD-531, a fungus obtained from the deep-sea sediment of cold seep in the South China Sea".DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS 195(2023):7.