Aptamer-conjugated magnetic Fe3O4@Au core-shell multifunctional nanoprobe: A three-in-one aptasensor for selective capture, sensitive SERS detection and efficient near-infrared light triggered photothermal therapy of Staphylococcus aureus

doi:10.1016/j.snb.2021.130879

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	Aptamer-conjugated magnetic Fe3O4@Au core-shell multifunctional nanoprobe: A three-in-one aptasensor for selective capture, sensitive SERS detection and efficient near-infrared light triggered photothermal therapy of Staphylococcus aureus
	W. S. Zhao; D. X. Zhang; T. X. Zhou; J. Huang; Y. S. Wang; B. X. Li; L. Chen; J. H. Yang and Y. Liu
刊名	Sensors and Actuators B-Chemical
	2022
卷号	350 页码:12
DOI	10.1016/j.snb.2021.130879
英文摘要	Early and accurate diagnosis of pathogenic bacteria is essential to prevent further infection from spreading and multiplying. Herein, an aptamer (Apt) biosensor based on Fe3O4@Au nanocomposites (NCs) has been proposed for capture, surface-enhanced Raman scattering (SERS) detection, and photothermal therapy (PTT) of S. aureus. Fe3O4@Au NCs become SERS substrate and photothermal agent due to superior surface plasmon properties and photothermal ability, while the aptamer immobilized on surface of Fe3O4@Au NCs acts as a capture agent. The detection limit of optimized Fe3O4@Au-Apt aptasensor for S. aureus is 25 cfu/mL, and cell capture efficiency (CCE) is as high as 68%. Moreover, our Fe3O4@Au-Apt NCs have high photothermal conversion efficiency of 39.28%, which have been proven as an excellent photothermal agent. As verified by experiments, Fe3O4@Au-Apt aptasensor is not only a promising tool to detect and photothermally inactivated S. aureus in milk samples, but also exhibits negligible cytotoxicity and good biocompatibility. This work shows a promising multifunctional nano-platform, which has great potential in specific recognition, sensitive SERS detection and PTT of S. aureus.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/66427]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	W. S. Zhao,D. X. Zhang,T. X. Zhou,et al. Aptamer-conjugated magnetic Fe3O4@Au core-shell multifunctional nanoprobe: A three-in-one aptasensor for selective capture, sensitive SERS detection and efficient near-infrared light triggered photothermal therapy of Staphylococcus aureus[J]. Sensors and Actuators B-Chemical,2022,350:12.
APA	W. S. Zhao.,D. X. Zhang.,T. X. Zhou.,J. Huang.,Y. S. Wang.,...&J. H. Yang and Y. Liu.(2022).Aptamer-conjugated magnetic Fe3O4@Au core-shell multifunctional nanoprobe: A three-in-one aptasensor for selective capture, sensitive SERS detection and efficient near-infrared light triggered photothermal therapy of Staphylococcus aureus.Sensors and Actuators B-Chemical,350,12.
MLA	W. S. Zhao,et al."Aptamer-conjugated magnetic Fe3O4@Au core-shell multifunctional nanoprobe: A three-in-one aptasensor for selective capture, sensitive SERS detection and efficient near-infrared light triggered photothermal therapy of Staphylococcus aureus".Sensors and Actuators B-Chemical 350(2022):12.