Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals

	Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals
	Sun, Yuqing 2; Zhao, Yuxin 1; Hu, Ke 1; Wang, Meng 2; Liu, Yong 4; Liu, Bing 2
刊名	TRANSLATIONAL PSYCHIATRY
	2023
卷号	13 期号:1
ISSN号	2158-3188
英文摘要	We aimed to investigate the relationship between spatiotemporal changes of amyloid deposition and Alzheimer's disease (AD) profiles in cognitively normal (CN) and those with mild cognitive impairment (MCI). Using a data-driven method and amyloid-PET data, we identified and validated two subtypes in two independent datasets (discovery dataset: N = 548, age = 72.4 +/- 6.78, 49% female; validation dataset: N = 348, age = 74.9 +/- 8.16, 47% female) from the Alzheimer's Disease Neuroimaging Initiative across a range of individuals who were CN or had MCI. The two subtypes showed distinct regional progression patterns and presented distinct genetic, clinical and biomarker characteristics. The cortex-priority subtype was more likely to show typical clinical syndromes of symptomatic AD and vice versa. Furthermore, the regional progression patterns were associated with clinical and biomarker profiles. In sum, our findings suggest that the spatiotemporal variants of amyloid depositions are in close association with disease trajectories; these findings may provide insight into the disease monitoring and enrollment of therapeutic trials in AD.
语种	英语
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/51801]
专题	自动化研究所_脑网络组研究中心
作者单位	1.University of Chinese Academy of Sciences, CAS 2.Beijing Normal University 3.Chinese Inst Brain Res 4.Beijing University of Posts & Telecommunications 5.Institute of Automation, CAS 6.Chinese Academy of Sciences Brainnetome Ctr
推荐引用方式 GB/T 7714	Sun, Yuqing,Zhao, Yuxin,Hu, Ke,et al. Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals[J]. TRANSLATIONAL PSYCHIATRY,2023,13(1).
APA	Sun, Yuqing,Zhao, Yuxin,Hu, Ke,Wang, Meng,Liu, Yong,&Liu, Bing.(2023).Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals.TRANSLATIONAL PSYCHIATRY,13(1).
MLA	Sun, Yuqing,et al."Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals".TRANSLATIONAL PSYCHIATRY 13.1(2023).