Potential roles of FoxO in promoting longevity in larger Argopecten scallops br

doi:10.1016/j.aquaculture.2022.738690

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Potential roles of FoxO in promoting longevity in larger Argopecten scallops br
	Wang, Yuan 2,3; Lu, Xia 1,3; Wang, Chunde 3,4; Ning, Junhao 3; Chen, Min 3; Yuan, Ke 2,3
刊名	AQUACULTURE
	2022-12-15
卷号	561 页码:15
关键词	Bivalve Argopecten scallops FoxO Longevity Larger size
ISSN号	0044-8486
DOI	10.1016/j.aquaculture.2022.738690
英文摘要	Bay scallops are commercially important bivalve species for fisheries and aquaculture in China, the USA, Peru and Chile, but their small size, short lifespan (<14 months) and serious inbreeding depression restrict the sustainable development of their aquaculture. Compared with bay scallops, some interspecific hybrids of bay scallops and Peruvian scallops exhibit longer lifespans and significantly larger sizes, which may result from the longevity genes of Peruvian scallops, which have lifespans of 7-10 years. The FoxO transcription factor integrates signals from different longevity-related pathways that play a crucial role in aging and longevity in terrestrial model organisms. However, limited information is available on its roles in the longevity of marine animals. Here, we extended this paradigm using Peruvian scallops and bay scallops, which have distinct lifespans. Cloning and sequence analysis of the FoxO ORFs (ApFoxO and AiFoxO) revealed 22 synonymous, 7 nonsynonymous SNPs and two InDels between the two species. The amino acid variations (Q27 and E28) near the AKT phosphorylation site (T21) may affect the activities of ApFoxO for longevity. Nutrient restriction could extend lifespan in terrestrial model organisms, and the expression of ApFoxO and AiFoxO both significantly increased under nutrient restriction, but the response in bay scallops was faster and more robust than that in Peruvian scallops. Furthermore, ionizing radiation caused significantly lower mortality and higher FoxO expression in Peruvian scallops. These results suggested that FoxO may play a protective role in longevity through nutrient availability and DNA repair for genomic stability. The significantly decreased expression of CAT and Mn-SOD and the increased beta-GAL activity (a marker for senescence) after FoxO downregulation suggested that FoxO may contribute to longevity by controlling ROS with its antioxidase activity. The results of our work provide the basis for understanding the role of FoxO in longevity in scallops and its potential as a biomarker for selecting larger hybrids to benefit scallop aquaculture.
资助项目	National Natural Science Foundation of China[4227061247] ; National Natural Science Foundation of China[31972791] ; Ear- marked Fund for Agriculture Seed Improvement Project of Shandong Province[2020LZGC016] ; Ear- marked Fund for Agriculture Seed Improvement Project of Shandong Province[2021TSGC1229] ; Scientific and Technological Project of Yantai, Shandong Province[2022XCZX083] ; Earmarked Fund for Shandong Modern AgroIndustry Technology Research System[SDAIT-14]
WOS关键词	INSULIN SIGNALING PATHWAY ; CALORIC RESTRICTION ; TRANSCRIPTION FACTORS ; EXPRESSION PROFILE ; BAY SCALLOP ; AKT ; METABOLISM ; DAF-16 ; LIFE ; RESISTANCE
WOS研究方向	Fisheries ; Marine & Freshwater Biology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000848310800005
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31651]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Lu, Xia
作者单位	1.17 Chunhui Rd, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Shandong, Peoples R China 4.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yuan,Lu, Xia,Wang, Chunde,et al. Potential roles of FoxO in promoting longevity in larger Argopecten scallops br[J]. AQUACULTURE,2022,561:15.
APA	Wang, Yuan,Lu, Xia,Wang, Chunde,Ning, Junhao,Chen, Min,&Yuan, Ke.(2022).Potential roles of FoxO in promoting longevity in larger Argopecten scallops br.AQUACULTURE,561,15.
MLA	Wang, Yuan,et al."Potential roles of FoxO in promoting longevity in larger Argopecten scallops br".AQUACULTURE 561(2022):15.